Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | San Antonio Bus Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. + Valley Transit | Bus | Gateway Station | San Antonio Bus Station | Fastest | ||||
Greyhound Lines, Inc. + Greyhound Lines Mexico | Bus | Gateway Station | San Antonio Bus Station | No tags | ||||
Greyhound Lines, Inc. + Valley Transit | Bus | Gateway Station | San Antonio Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Gateway Station | Pearl District | No tags |
Last refresh of the prices: Yesterday at 7:58 PM CST.
Compare 2 ways to go from St. Louis to San Antonio
Among the sustainable travel choices, the bus stands out as a good way to reach San Antonio. The journey takes about 22 hours 30 minutes, and with fares starting at just $104, it presents an excellent value for a comfortable ride.
Compare bus companies
Where are the popular stops in St. Louis and San Antonio?
Frequently asked questions about travelling from St. Louis to San Antonio, US by bus
What is the distance between St. Louis and San Antonio?
The distance covered from St. Louis to San Antonio is 1278 km (793 miles).
What are the departure and arrival locations for buses traveling from St. Louis to San Antonio?
Buses traveling this route start their trip at Gateway Station, in St. Louis, and end it at San Antonio Bus Station, in San Antonio.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to San Antonio, US was searched and found on Nov 20, 2025 with a price of $152To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Antonio, US, as early as possible.
You can expect to pay from $152 to $303 for a bus ticket from St. Louis to San Antonio, US based on the last 2 days. You can expect to find the cheapest price for the trip at $152 which is on 2025-11-20.
