How much is the bus ticket from San Francisco to Santa Ana?

The cheapest bus tickets from San Francisco to Santa Ana start from $68. The average price for this route is around $121. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from San Francisco to Santa Ana?

The average bus trip duration from San Francisco to Santa Ana is 13h 40m, covering a distance of 382 miles (616 km). The quickest bus can get you there in 10h 55m and is operated by Greyhound .

Which bus companies service the San Francisco to Santa Ana route?

Several major bus companies operate on this route with 6 buses available per day, including services from Greyhound , FlixBus .

What is the earliest and latest departure time for the bus from San Francisco to Santa Ana?

The earliest bus departs from San Francisco to Santa Ana at 6:30am. And the latest bus departs at 10:40pm.

What are the CO₂ emissions for the bus trip from San Francisco to Santa Ana?

A bus trip from San Francisco to Santa Ana generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from San Francisco to Santa Ana?

According to Busbud customers, the highest-rated bus company on this route is Greyhound , with an average rating of 3.5 out of 5 stars based on 87387 reviews.

Which bus company has the best Wi-Fi from San Francisco to Santa Ana?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from San Francisco to Santa Ana?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from San Francisco to Santa Ana?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus San Francisco to Santa Ana from $46 | Refundable Tickets

Previously seen trips

Next departures for San Francisco to Santa Ana on November 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	6:30am	San Francisco Bus Station	15h 30m	10:00pm	Santa Ana Bus Station	No tags
FlixBus + Greyhound	Bus	8:30am	409 Townsend St, SF	13h 30m	10:00pm	Santa Ana Bus Station	No tags
	Bus	10:40pm	San Francisco Bus Station	10h 50m	9:30am	Santa Ana Bus Station	No tags
Greyhound + FlixBus	Bus	11:25pm	409 Townsend St, SF	10h 5m	9:30am	Santa Ana Bus Station	No tags
	Bus	10:40pm	San Francisco Bus Station	10h 50m	9:30am	Santa Ana Bus Station	No tags

Get from San Francisco to Santa Ana

This route is served by bus only

The journey takes about 13 hours 40 minutes and with fares starting at just $68, it presents an excellent value for a comfortable ride.

6bus per day

13h 40mAverage Duration

382 milesDistance

15kgCO₂ emissions

Where are the popular stops in San Francisco and Santa Ana?

Stops in San Francisco

A
Hyde/Beach (Fisherman's Wharf)
700 Beach Street, San Francisco, CA 94109, USA
Visit page
B
Powell Station
25 Cyril Magnin St , San Francisco, CA 94102-2812
C
Union Square Hilton
255 Mason St,, San Francisco, CA 94102-2114
D
San Francisco Greyhound Station
200 Folsom St, San Francisco, CA 94105
E
444 Townsend St.
444 Townsend St, San Francisco, CA 94107, USA

Stops in Santa Ana

A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701
B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA

Compare bus companies

Greyhound

3.5/587,408 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,475 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from San Francisco, US to Santa Ana, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from San Francisco to Santa Ana?
The cheapest bus tickets from San Francisco to Santa Ana start from $68. The average price for this route is around $121. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Francisco to Santa Ana?
The average bus trip duration from San Francisco to Santa Ana is 13h 40m, covering a distance of 382 miles (616 km). The quickest bus can get you there in 10h 55m and is operated by Greyhound.
Which bus companies service the San Francisco to Santa Ana route?
Several major bus companies operate on this route with 6 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from San Francisco to Santa Ana?
The earliest bus departs from San Francisco to Santa Ana at 6:30am. And the latest bus departs at 10:40pm.
What are the CO₂ emissions for the bus trip from San Francisco to Santa Ana?
A bus trip from San Francisco to Santa Ana generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from San Francisco to Santa Ana?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from San Francisco to Santa Ana?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from San Francisco to Santa Ana?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Francisco to Santa Ana?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/27

No data

11/28

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Today

$55

11/30

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12/01

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12/02

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12/03

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12/04

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The cheapest trip from San Francisco, US to Santa Ana, US was searched and found on Nov 29, 2025 with a price of $55

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Francisco, US to Santa Ana, US, as early as possible.