Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Pearl District | Tupelo (Brothers Quick Stop) | Cheapest | ||||
Greyhound Lines Mexico + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Tupelo (Brothers Quick Stop) | Fastest | ||||
 | Bus | San Antonio Bus Station | Tupelo (Brothers Quick Stop) | No tags | ||||
Valley Transit + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Tupelo (Brothers Quick Stop) | No tags | ||||
Greyhound Lines Mexico + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Tupelo (Brothers Quick Stop) | No tags |
Last refresh of the prices: Last Monday at 12:04 AM CST.
Get from San Antonio to Tupelo
The journey takes about 1 day, 1 hour 50 minutes and with fares starting at just $134, it presents an excellent value for a comfortable ride.
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Frequently asked questions about traveling from San Antonio, US to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Antonio to Tupelo?
The cheapest bus tickets from San Antonio to Tupelo start from $134. The average price for this route is around $177. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Antonio to Tupelo?
The average bus trip duration from San Antonio to Tupelo is 1d 1h, covering a distance of 663 miles (1069 km). The quickest bus can get you there in 22h 5m and is operated by Greyhound.
Which bus companies service the San Antonio to Tupelo route?
Several major bus companies operate on this route with 4 buses available per day, including services from Greyhound, Valley Transit, FlixBus.
What is the earliest and latest departure time for the bus from San Antonio to Tupelo?
The earliest bus departs from San Antonio to Tupelo at 1:30am. And the latest bus departs at 9:15pm.
What are the CO₂ emissions for the bus trip from San Antonio to Tupelo?
A bus trip from San Antonio to Tupelo generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from San Antonio to Tupelo?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87500 reviews.
Which bus company has the best Wi-Fi from San Antonio to Tupelo?
Based on reviews on Busbud, the bus company Valley Transit has the best Wi-Fi rating with a score of 2.8.
Which bus company has the most timely service from San Antonio to Tupelo?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Antonio to Tupelo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Antonio, US to Tupelo was searched and found on Jan 15, 2026 with a price of $147To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Antonio, US to Tupelo, as early as possible.
You can expect to pay from $147 to $198 for a bus ticket from San Antonio, US to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $198 which is on 2026-01-17.
