Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Houston Bus Station | Tupelo (Brothers Quick Stop) | No tags | ||||
FlixBus + Greyhound | Bus | Houston Uptown/Upper Kirby | Tupelo (Brothers Quick Stop) | No tags | ||||
FlixBus + Greyhound | Bus | Downtown Gray & Smith | Tupelo (Brothers Quick Stop) | No tags | ||||
Greyhound + FlixBus | Bus | Houston Uptown/Upper Kirby | Tupelo (Brothers Quick Stop) | No tags | ||||
| Bus | Houston Bus Station | Tupelo (Brothers Quick Stop) | No tags |
Get from Houston to Tupelo
The journey takes about 22 hours 35 minutes and with fares starting at just $100, it presents an excellent value for a comfortable ride.
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Frequently asked questions about traveling from Houston, US to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Houston to Tupelo?
The cheapest bus tickets from Houston to Tupelo start from $100. The average price for this route is around $126. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Houston to Tupelo?
The average bus trip duration from Houston to Tupelo is 22h 35m, covering a distance of 485 miles (781 km). The quickest bus can get you there in 20h 30m and is operated by Greyhound.
Which bus companies service the Houston to Tupelo route?
Several major bus companies operate on this route with 15 buses available per day, including services from Greyhound, FlixBus, Valley Transit.
What is the earliest and latest departure time for the bus from Houston to Tupelo?
The earliest bus departs from Houston to Tupelo at 12:05am. And the latest bus departs at 11:20pm.
What are the CO₂ emissions for the bus trip from Houston to Tupelo?
A bus trip from Houston to Tupelo generates an estimated 20 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Houston to Tupelo?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Houston to Tupelo?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Houston to Tupelo?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Houston to Tupelo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Houston, US to Tupelo was searched and found on Nov 28, 2025 with a price of $186To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Houston, US to Tupelo, as early as possible.
You can expect to pay from $186 to $317 for a bus ticket from Houston, US to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $237 which is on 2025-12-01.
