Next departures for Philadelphia to Greenville on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
1116 Woodruff Rd
Cheapest
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
1116 Woodruff Rd
No tags
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
No tags
Bus
Schuylkill & Walnut
1116 Woodruff Rd
No tags
Next departures for Philadelphia to Greenville on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
1116 Woodruff Rd
Cheapest
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
1116 Woodruff Rd
No tags
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
No tags
Bus
Schuylkill & Walnut
1116 Woodruff Rd
No tags
Next departures for Philadelphia to Greenville on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
1116 Woodruff Rd
Cheapest
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
1116 Woodruff Rd
No tags
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
No tags
Bus
Schuylkill & Walnut
1116 Woodruff Rd
No tags
Next departures for Philadelphia to Greenville on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
1116 Woodruff Rd
Cheapest
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
1116 Woodruff Rd
No tags
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
No tags
Bus
Schuylkill & Walnut
1116 Woodruff Rd
No tags
Next departures for Philadelphia to Greenville on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
1116 Woodruff Rd
Cheapest
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
1116 Woodruff Rd
No tags
Bus
Philadelphia, 199 Spring Garden St
1116 Woodruff Rd
No tags
Bus
Schuylkill & Walnut
1116 Woodruff Rd
No tags
Last refresh of the prices: Yesterday at 5:49 AM EST.
Compare 2 ways to go from Philadelphia to Greenville
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 18 hours 35 minutes and with fares starting at just $77, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Off of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USAIndependence Travel Center
C - #2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA
D - Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA
E - Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA
F - NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Stops in Greenville
A - Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B - Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Frequently asked questions about traveling from Philadelphia, PA to Greenville, SC by bus
What is the distance between Philadelphia and Greenville?
The distance separating Philadelphia and Greenville is 530 miles (855 km).
What are the departure and arrival stations when taking the bus from Philadelphia to Greenville?
If you're headed to Greenville from Philadelphia, chances are that your bus will leave from Philadelphia Airport and arrive at Guadalajara Supermarket Bus Stop. These are the main departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
$100
11/19
$100
Today
$94
11/21
$103
11/22
$100
11/23
$103
11/24
$116
11/25
$161
The cheapest trip from Philadelphia, PA to Greenville, SC was searched and found on Nov 20, 2025 with a price of $94
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Greenville, SC, as early as possible.
You can expect to pay from $94 to $279 for a bus ticket from Philadelphia, PA to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $100 which is on 2025-11-22.
What's the cheapest way to go from Philadelphia, PA to Greenville, SC?
The bus is the cheapest travel choice for this destination