How much is the bus ticket from Chicago to Greenville?

The cheapest bus tickets from Chicago to Greenville start from $87. The average price for this route is around $142. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Chicago to Greenville?

The average bus trip duration from Chicago to Greenville is 21h 10m, covering a distance of 556 miles (896 km). The quickest bus can get you there in 20h 5m and is operated by Greyhound .

Which bus companies service the Chicago to Greenville route?

Several major bus companies operate on this route with 16 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Chicago to Greenville?

The earliest bus departs from Chicago to Greenville at 5:25am. And the latest bus departs at 11:50pm.

What are the CO₂ emissions for the bus trip from Chicago to Greenville?

A bus trip from Chicago to Greenville generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Chicago to Greenville?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 11828 reviews.

Which bus company has the best Wi-Fi from Chicago to Greenville?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Chicago to Greenville?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Chicago to Greenville?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Chicago to Greenville from $81 | Refundable Tickets

Next bus departures

Next departures for Chicago to Greenville on January 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	2:10pm	Chicago 95Th & Dan Ryan	20h 50m	12:00pm	1116 Woodruff Rd	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	1:30pm	Chicago 95Th & Dan Ryan	20h 10m	10:40am	1116 Woodruff Rd	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	1:00pm	Downtown Greyhound Station	20h 40m	10:40am	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:45pm	Downtown Greyhound Station	20h 15m	12:00pm	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:50pm	Downtown Greyhound Station	22h 5m	9:55pm	1116 Woodruff Rd	No tags

Next departures for Chicago to Greenville on January 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	9:40am	Downtown Greyhound Station	20h 25m	7:05am	1116 Woodruff Rd	Cheapest
	Bus	10:00am	537-517 W. Jackson Blvd	20h 5m	7:05am	1116 Woodruff Rd	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	1:00pm	Downtown Greyhound Station	20h 40m	10:40am	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:45pm	Downtown Greyhound Station	20h 15m	12:00pm	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:50pm	Downtown Greyhound Station	22h 5m	9:55pm	1116 Woodruff Rd	No tags

Next departures for Chicago to Greenville on January 16
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:50pm	Chicago 95Th & Dan Ryan	1d 6h	7:05am	1116 Woodruff Rd	Cheapest
	Bus	10:00am	537-517 W. Jackson Blvd	20h 5m	7:05am	1116 Woodruff Rd	Fastest
	Bus	9:40am	Downtown Greyhound Station	20h 25m	7:05am	1116 Woodruff Rd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:00pm	Downtown Greyhound Station	20h 40m	10:40am	1116 Woodruff Rd	No tags
	Bus	6:00pm	Downtown Greyhound Station	21h 10m	4:10pm	1116 Woodruff Rd	No tags

Next departures for Chicago to Greenville on January 17
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:30pm	Chicago 95Th & Dan Ryan	20h 10m	10:40am	1116 Woodruff Rd	Cheapest
	Bus	10:00am	537-517 W. Jackson Blvd	20h 5m	7:05am	1116 Woodruff Rd	Fastest
	Bus	9:40am	Downtown Greyhound Station	20h 25m	7:05am	1116 Woodruff Rd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:00pm	Downtown Greyhound Station	20h 40m	10:40am	1116 Woodruff Rd	No tags
	Bus	6:00pm	Downtown Greyhound Station	21h 10m	4:10pm	1116 Woodruff Rd	No tags

Next departures for Chicago to Greenville on January 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	5:45am	Chicago 95Th & Dan Ryan	1d	7:05am	1116 Woodruff Rd	Cheapest
	Bus	10:00am	537-517 W. Jackson Blvd	20h 5m	7:05am	1116 Woodruff Rd	Fastest
	Bus	9:40am	Downtown Greyhound Station	20h 25m	7:05am	1116 Woodruff Rd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:00pm	Downtown Greyhound Station	20h 40m	10:40am	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:50pm	Downtown Greyhound Station	22h 5m	9:55pm	1116 Woodruff Rd	No tags

Next departures for Chicago to Greenville on January 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:30pm	Chicago 95Th & Dan Ryan	20h 10m	10:40am	1116 Woodruff Rd	Cheapest
	Bus	10:00am	537-517 W. Jackson Blvd	20h 5m	7:05am	1116 Woodruff Rd	Fastest
	Bus	9:40am	Downtown Greyhound Station	20h 25m	7:05am	1116 Woodruff Rd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:00pm	Downtown Greyhound Station	20h 40m	10:40am	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:50pm	Downtown Greyhound Station	22h 5m	9:55pm	1116 Woodruff Rd	No tags

Last refresh of the prices: Last Sunday at 6:22 AM CST.

Compare 2 ways to go from Chicago to Greenville

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as the good way to reach Greenville. The journey takes about 21 hours 10 minutes and with fares starting at just $87, it presents an excellent value for a comfortable ride.

16bus per day

21h 10mAverage Duration

556 milesDistance

22kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$87 - $315	Average Duration21h 10m	CO₂ emissions 22kg CO₂e
Train	Average Price$193 - $1,805	Average Duration1d 9h	CO₂ emissions 82kg CO₂e

Where are the popular stops in Chicago and Greenville?

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page Map
B
Chicago O'Hare International Airport
Visit page Map
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
Map
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
Map
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
Map
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Map

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
Map
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Map

Compare bus companies

FlixBus

3.5/512,043 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,500 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound Chicago Greenville recent customer reviews

Good Service

Niraj P.

December 16, 2018

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Chicago to Greenville, SC by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Chicago to Greenville?
The cheapest bus tickets from Chicago to Greenville start from $87. The average price for this route is around $142. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Greenville?
The average bus trip duration from Chicago to Greenville is 21h 10m, covering a distance of 556 miles (896 km). The quickest bus can get you there in 20h 5m and is operated by Greyhound.
Which bus companies service the Chicago to Greenville route?
Several major bus companies operate on this route with 16 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Chicago to Greenville?
The earliest bus departs from Chicago to Greenville at 5:25am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Chicago to Greenville?
A bus trip from Chicago to Greenville generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Chicago to Greenville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11828 reviews.
Which bus company has the best Wi-Fi from Chicago to Greenville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Chicago to Greenville?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/12

$171

01/13

$164

Today

$125

01/15

$133

01/16

$149

01/17

$145

01/18

$117

01/19

$138

The cheapest trip from Chicago to Greenville, SC was searched and found on Jan 18, 2026 with a price of $117

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, SC, as early as possible.

You can expect to pay from $117 to $171 for a bus ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $117 which is on 2026-01-18.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.