Find coaches from Chicago to Greenville, SC

Next bus departures

Next departures from Chicago to Greenville on 21 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
1116 Woodruff RdCheapest
Greyhound Lines, Inc.Bus
537-517 W. Jackson Blvd
1116 Woodruff RdFastest
Greyhound Lines, Inc.Bus
Downtown Greyhound Station
1116 Woodruff RdNo tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
1116 Woodruff RdNo tags
FlixBusBus
Downtown Greyhound Station
1116 Woodruff RdNo tags

Last refresh of the prices: Yesterday at 11:16 AM CST.

Compare 2 ways to travel from Chicago to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 20 hours 50 minutes and with fares starting at just R 1 582, it presents an excellent value for a comfortable ride.

13bus per day
20h 50mAverage duration
896 kmDistance
22kgCO₂ emissions
Bus
Average priceR 1 582 - R 6 876Average duration20h 50m
22kg CO₂e
Train
Average priceR 3 820 - R 20 822Average duration1d 9h
82kg CO₂e

Frequently asked questions about travelling from Chicago to Greenville, SC by bus

  1. How much does a bus ticket from Chicago to Greenville cost?

    The bus ticket price from Chicago to Greenville starts at R 1 582. The best way to find cheap bus tickets from Chicago to Greenville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Chicago to Greenville?

    The average travel time between Chicago and Greenville is around 20h 50m, although the fastest bus will take about 18h 50m. This is the time it takes to travel the 904 km that separates the two cities.

  3. How many daily bus connections are there between Chicago and Greenville?

    The number of buses from Chicago to Greenville can differ depending on the day of the week. On average, there are 13 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Chicago to Greenville by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Chicago to Greenville?

    When taking the bus from Chicago to Greenville, you can travel comfortably and safely with FlixBus, Greyhound.

  5. What are the departure and arrival stations when taking the bus from Chicago to Greenville?

    Buses travelling between Chicago and Greenville leave from Downtown Greyhound Station or Chicago O'Hare International Airport and arrive at Guadalajara Supermarket Bus Stop, Greenville Bus Station.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
18/11
No data
19/11
No data
Today
R 2 700
21/11
R 2 656
22/11
R 1 765
23/11
No data
24/11
R 3 591
25/11
R 3 767
busbud logoThe cheapest trip from Chicago to Greenville, SC was searched and found on 22 Nov 2025 with a price of R 1 765

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, SC as early as possible.

You can expect to pay from R 1 765 to R 4 852 for a bus ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 765, which is on 2025-11-22.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

What's the cheapest way to go from Chicago to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

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