How much is the bus ticket from Chicago to Greenville?

The cheapest bus tickets from Chicago to Greenville start at R 1 456. The average price for this route is around R 2 196. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.

How long is the bus journey from Chicago to Greenville?

The average bus journey time from Chicago to Greenville is 21h 10m, covering a distance of 896 km. The fastest bus gets you there in 20h 5m and is operated by Greyhound .

Which bus companies service the Chicago to Greenville route?

Several major bus companies operate on this route with 15 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Chicago to Greenville?

The earliest bus departs from Chicago to Greenville at 05:25. And the latest bus departs at 23:50.

What are the CO₂ emissions for the bus trip from Chicago to Greenville?

A bus trip from Chicago to Greenville produces an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.

What is the best bus company from Chicago to Greenville?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 12050 reviews.

Which bus company has the best Wi-Fi from Chicago to Greenville?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company offers the most punctual service from Chicago to Greenville?

According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Chicago to Greenville?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Chicago to Greenville from R 1 353 | Refundable Tickets

Next bus departures

Next departures from Chicago to Greenville on 20 January
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	23:50	Chicago 95Th & Dan Ryan	1d 6h	07:05	1116 Woodruff Rd	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	23:40	Chicago 95Th & Dan Ryan	21h 15m	21:55	1116 Woodruff Rd	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	22:50	Downtown Greyhound Station	22h 5m	21:55	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	23:10	537-517 W. Jackson Blvd	21h 45m	21:55	1116 Woodruff Rd	No tags

Next departures from Chicago to Greenville on 21 January
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	13:30	Chicago 95Th & Dan Ryan	20h 10m	10:40	1116 Woodruff Rd	Cheapest
	Bus	10:00	537-517 W. Jackson Blvd	20h 5m	07:05	1116 Woodruff Rd	Fastest
	Bus	09:40	Downtown Greyhound Station	20h 25m	07:05	1116 Woodruff Rd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	13:00	Downtown Greyhound Station	20h 40m	10:40	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	14:45	Downtown Greyhound Station	20h 15m	12:00	1116 Woodruff Rd	No tags

Next departures from Chicago to Greenville on 22 January
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	18:40	Chicago 95Th & Dan Ryan	20h 30m	16:10	1116 Woodruff Rd	Cheapest
	Bus	10:00	537-517 W. Jackson Blvd	20h 5m	07:05	1116 Woodruff Rd	Fastest
	Bus	09:40	Downtown Greyhound Station	20h 25m	07:05	1116 Woodruff Rd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	13:00	Downtown Greyhound Station	20h 40m	10:40	1116 Woodruff Rd	No tags
	Bus	18:00	Downtown Greyhound Station	21h 10m	16:10	1116 Woodruff Rd	No tags

Next departures from Chicago to Greenville on 24 January
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	13:30	Chicago 95Th & Dan Ryan	20h 10m	10:40	1116 Woodruff Rd	Cheapest
	Bus	10:00	537-517 W. Jackson Blvd	20h 5m	07:05	1116 Woodruff Rd	Fastest
	Bus	09:40	Downtown Greyhound Station	20h 25m	07:05	1116 Woodruff Rd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	13:00	Downtown Greyhound Station	20h 40m	10:40	1116 Woodruff Rd	No tags
	Bus	18:00	Downtown Greyhound Station	21h 10m	16:10	1116 Woodruff Rd	No tags

Next departures from Chicago to Greenville on 26 January
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	23:40	Chicago 95Th & Dan Ryan	21h 15m	21:55	1116 Woodruff Rd	Cheapest
	Bus	10:00	537-517 W. Jackson Blvd	20h 5m	07:05	1116 Woodruff Rd	Fastest
	Bus	09:40	Downtown Greyhound Station	20h 25m	07:05	1116 Woodruff Rd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	13:00	Downtown Greyhound Station	20h 40m	10:40	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	22:50	Downtown Greyhound Station	22h 5m	21:55	1116 Woodruff Rd	No tags

Last refresh of the prices: Yesterday at 1:32 PM CST.

Compare 2 ways to travel from Chicago to Greenville

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Greenville. The journey takes about 21 hours 10 minutes and with fares starting at just R 1 456, it presents an excellent value for a comfortable ride.

15bus per day

21h 10mAverage duration

896 kmDistance

22kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average priceR 1 456 - R 5 430	Average duration21h 10m	CO₂ emissions 22kg CO₂e
Train	Average priceR 2 960 - R 32 057	Average duration1d 9h	CO₂ emissions 82kg CO₂e

Where are the popular stops in Chicago and Greenville?

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page Map
B
Chicago O'Hare International Airport
Map
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
Map
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
Map
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
Map
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Map

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
Map
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Map

Compare bus companies

FlixBus

3.5/512 119 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

WiFi2.7

Greyhound

3.5/587 515 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

WiFi2.4

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from Chicago to Greenville, SC by bus

Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.

How much is the bus ticket from Chicago to Greenville?
The cheapest bus tickets from Chicago to Greenville start at R 1 456. The average price for this route is around R 2 196. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Chicago to Greenville?
The average bus journey time from Chicago to Greenville is 21h 10m, covering a distance of 896 km. The fastest bus gets you there in 20h 5m and is operated by Greyhound.
Which bus companies service the Chicago to Greenville route?
Several major bus companies operate on this route with 15 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Chicago to Greenville?
The earliest bus departs from Chicago to Greenville at 05:25. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Chicago to Greenville?
A bus trip from Chicago to Greenville produces an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Chicago to Greenville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12050 reviews.
Which bus company has the best Wi-Fi from Chicago to Greenville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Chicago to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

18/01

R 2 916

19/01

R 3 747

Today

R 2 932

21/01

R 2 050

22/01

R 1 907

23/01

R 1 907

24/01

R 2 025

25/01

R 1 689

The cheapest trip from Chicago to Greenville, SC was searched and found on 25 Jan 2026 with a price of R 1 689

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, SC as early as possible.

You can expect to pay from R 1 689 to R 3 747 for a bus ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 689, which is on 2026-01-25.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.