Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | 1116 Woodruff Rd | Cheapest | ||||
 | Bus | 537-517 W. Jackson Blvd | 1116 Woodruff Rd | Fastest | ||||
| Bus | Downtown Greyhound Station | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Greyhound Station | 1116 Woodruff Rd | No tags | ||||
 | Bus | Downtown Greyhound Station | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Today at 08:32 CST.
Compare 2 ways to travel from Chicago to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 20 hours 50 minutes and with fares starting at just £74, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and Greenville?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Frequently asked questions about travelling by bus from Chicago to Greenville, SC
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Chicago to Greenville?
The cheapest coach tickets from Chicago to Greenville start from £74. The average price for this route is around £116. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Chicago to Greenville?
The average bus journey time from Chicago to Greenville is 20h 50m, covering a distance of 556 miles. The fastest bus can take you there in 18h 50m and is operated by FlixBus.
Which bus companies service the Chicago to Greenville route?
What is the earliest and latest departure time for the bus from Chicago to Greenville?
The earliest bus departs from Chicago to Greenville at 00:30. And the latest bus departs at 23:59.
What are the CO₂ emissions for the bus trip from Chicago to Greenville?
A bus journey from Chicago to Greenville produces an estimated 22 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Chicago to Greenville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which company has the best Wi-Fi from Chicago to Greenville?
Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Chicago to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Greenville, SC was searched and found on 3 Dec 2025 with a price of £81To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, SC as early as possible.
You can expect to pay from £81 to £278 for a bus ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at £81, which is on 2025-12-03.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Chicago to Greenville, SC?
The bus is the cheapest travel choice for this destination
