Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 199 Spring Garden St. | 1116 Woodruff Rd | Cheapest | ||||
 | Bus | Philadelphia, 199 Spring Garden St | 1116 Woodruff Rd | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 199 Spring Garden St. | 1116 Woodruff Rd | No tags | ||||
| Bus | Philadelphia, 199 Spring Garden St | 1116 Woodruff Rd | No tags | ||||
| Bus | Schuylkill & Walnut | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Last Tuesday at 14:07 EST.
Compare 2 ways to travel from Philadelphia to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 18 hours 35 minutes and with fares starting at just £63, it presents an excellent value for a comfortable ride.
Where are the popular stops in Philadelphia and Greenville?
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
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Frequently asked questions about travelling by bus from Philadelphia, PA to Greenville, SC
What's the distance between Philadelphia and Greenville by coach?
The distance between Philadelphia and Greenville by coach is approximately 530 miles (855 km).
What is the best way to go from Philadelphia to Greenville without flying?
You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Philadelphia, PA to Greenville, SC was searched and found on 2 Dec 2025 with a price of £71To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Greenville, SC as early as possible.
You can expect to pay from £71 to £251 for a bus ticket from Philadelphia, PA to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at £71, which is on 2025-12-02.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Philadelphia, PA to Greenville, SC?
The bus is the cheapest travel choice for this destination
