Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 199 Spring Garden St. | 1116 Woodruff Rd | Cheapest | ||||
 | Bus | Philadelphia, 199 Spring Garden St | 1116 Woodruff Rd | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 199 Spring Garden St. | 1116 Woodruff Rd | No tags | ||||
| Bus | Philadelphia, 199 Spring Garden St | 1116 Woodruff Rd | No tags | ||||
| Bus | Schuylkill & Walnut | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Last Tuesday at 2:07 PM EST.
Compare 2 ways to go from Philadelphia to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 18 hours 35 minutes, and with fares starting at just $116, it presents an excellent value for a comfortable ride.
Where are the popular stops in Philadelphia and Greenville?
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Frequently asked questions about travelling from Philadelphia, PA to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Philadelphia to Greenville?
The cheapest bus tickets from Philadelphia to Greenville start from $116. The average price for this route is around $170. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Philadelphia to Greenville?
The average bus travel time from Philadelphia to Greenville is 18h 35m, covering a distance of 850 km. The quickest bus can get you there in 14h 5m and is operated by FlixBus.
Which bus companies service the Philadelphia to Greenville route?
What are the earliest and latest departure times for the bus from Philadelphia to Greenville?
The earliest bus departs from Philadelphia to Greenville at 2:00am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Philadelphia to Greenville?
A bus trip from Philadelphia to Greenville generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Philadelphia to Greenville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Philadelphia to Greenville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Philadelphia to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Philadelphia to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Philadelphia, PA to Greenville, SC was searched and found on Dec 2, 2025 with a price of $131To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Greenville, SC, as early as possible.
You can expect to pay from $131 to $466 for a bus ticket from Philadelphia, PA to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $131 which is on 2025-12-02.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Philadelphia, PA to Greenville, SC?
The bus is the cheapest travel choice for this destination
