Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 199 Spring Garden St. | 1116 Woodruff Rd | Cheapest | ||||
 | Bus | Philadelphia, 199 Spring Garden St | 1116 Woodruff Rd | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 199 Spring Garden St. | 1116 Woodruff Rd | No tags | ||||
| Bus | Philadelphia, 199 Spring Garden St | 1116 Woodruff Rd | No tags | ||||
| Bus | Schuylkill & Walnut | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Yesterday at 5:52 AM EST.
Compare 2 ways to go from Philadelphia to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 18 hours 35 minutes, and with fares starting at just $116, it presents an excellent value for a comfortable ride.
Where are the popular stops in Philadelphia and Greenville?
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
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Frequently asked questions about travelling from Philadelphia, PA to Greenville, SC by bus
What is the distance between Philadelphia and Greenville?
The distance between Philadelphia and Greenville is around 855 km (530 miles).
What are the departure and arrival locations for buses traveling from Philadelphia to Greenville?
Buses traveling this route start their trip at Philadelphia Airport, in Philadelphia, and end it at Guadalajara Supermarket Bus Stop, in Greenville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Philadelphia, PA to Greenville, SC was searched and found on Nov 27, 2025 with a price of $154To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Greenville, SC, as early as possible.
You can expect to pay from $154 to $468 for a bus ticket from Philadelphia, PA to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $154 which is on 2025-11-27.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Philadelphia, PA to Greenville, SC?
The bus is the cheapest travel choice for this destination
