Bus from Detroit, MI to Greenville, SC: Tickets & Schedules
Previously seen trips
Next departures for Detroit to Greenville on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
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Recommended
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Greyhound + FlixBus
Bus
Detroit Bus Station
1116 Woodruff Rd
No tags
FlixBus + Greyhound
Bus
Detroit Bus Station
1116 Woodruff Rd
No tags
Bus
Detroit Bus Station
1116 Woodruff Rd
No tags
Greyhound + FlixBus
Bus
Detroit Bus Station
1116 Woodruff Rd
No tags
Bus
Detroit Bus Station
1116 Woodruff Rd
No tags
Compare 2 ways to go from Detroit to Greenville
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 1 day, 25 minutes and with fares starting at just $92, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Based on 5607 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $270
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Detroit, MI to Greenville, SC by bus
What is the distance between Detroit and Greenville?
The distance between the two cities is 518 miles (835 km).
What are the departure and arrival stations when taking the bus from Detroit to Greenville?
If you're headed to Greenville from Detroit, chances are that your bus will depart from Detroit Bus Station and arrive at Guadalajara Supermarket Bus Stop. These are the main departure and arrival locations on this route, but you can also find other options that could better fit your plans.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/24
No data
11/25
$195
Today
No data
11/27
No data
11/28
No data
11/29
$119
11/30
$149
12/01
$164
The cheapest trip from Detroit, MI to Greenville, SC was searched and found on Nov 29, 2025 with a price of $119
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Greenville, SC, as early as possible.
You can expect to pay from $119 to $1,745 for a bus ticket from Detroit, MI to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $119 which is on 2025-11-29.
What's the cheapest way to go from Detroit, MI to Greenville, SC?
The bus is the cheapest travel choice for this destination
The cheapest trip from Detroit, MI to Greenville, SC was searched and found on Nov 29, 2025 with a price of $119
The bus is the cheapest travel choice for this destination
