Bus from Detroit, MI to Greenville, SC: Tickets & Timetables

Previously seen journeys

Next departures from Detroit to Greenville on 1 December
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
Bus
Detroit Bus Station
1116 Woodruff RdNo tags
FlixBus + Greyhound
Bus
Detroit Bus Station
1116 Woodruff RdNo tags
GreyhoundBus
Detroit Bus Station
1116 Woodruff RdNo tags
Greyhound + FlixBus
Bus
Detroit Bus Station
1116 Woodruff RdNo tags
GreyhoundBus
Detroit Bus Station
1116 Woodruff RdNo tags

Compare 2 ways to travel from Detroit to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 1 day, 25 minutes and with fares starting at just £71, it presents an excellent value for a comfortable ride.

3bus per day
1d Average duration
519 milesDistance
21kgCO₂ emissions
Average price£71 - £356Average duration1d
21kg CO₂e
Average price£197 - £473Average duration1d 19h
76kg CO₂e

Frequently asked questions about travelling by bus from Detroit, MI to Greenville, SC

Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

  1. How much is the bus ticket from Detroit to Greenville?

    The cheapest coach tickets from Detroit to Greenville start from £71. The average price for this route is around £95. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus journey from Detroit to Greenville?

    The average bus journey time from Detroit to Greenville is 1d , covering a distance of 519 miles. The fastest bus can take you there in 18h 20m and is operated by Greyhound.

  3. Which bus companies service the Detroit to Greenville route?

    Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound, Amtrak, FlixBus.

  4. What is the earliest and latest departure time for the bus from Detroit to Greenville?

    The earliest bus departs from Detroit to Greenville at 06:40. And the latest bus departs at 23:25.

  5. What are the CO₂ emissions for the bus trip from Detroit to Greenville?

    A bus journey from Detroit to Greenville produces an estimated 21 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.

  6. Which is the best bus company from Detroit to Greenville?

    According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5597 reviews.

  7. Which company has the best Wi-Fi from Detroit to Greenville?

    Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.

  8. Which bus company offers the most punctual service from Detroit to Greenville?

    According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.

  9. Which bus company has the cleanest buses from Detroit to Greenville?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/11
No data
29/11
£190
Today
£116
01/12
£127
02/12
No data
03/12
No data
04/12
£69
05/12
No data
busbud logoThe cheapest trip from Detroit, MI to Greenville, SC was searched and found on 4 Dec 2025 with a price of £69

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Greenville, SC as early as possible.

You can expect to pay from £69 to £258 for a bus ticket from Detroit, MI to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at £69, which is on 2025-12-04.

What's the cheapest way to go from Detroit, MI to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

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