Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Niagara Frontier Transportation Authority | Gateway Station | CheapestFastest |
Last refresh of the prices: Yesterday at 5:29 PM EST.
Compare 2 ways to go from Buffalo to St. Louis
Among the sustainable travel choices, the train stands out as the good way to reach St. Louis. The journey takes about 20 hours 28 minutes and with fares starting at just $193, it presents an excellent value for a comfortable ride.
Where are the popular stops in Buffalo and St. Louis?
Stops in Buffalo
- B185 Ellicott St, Buffalo, NY 14203, USA
- C75 Exchange St, Buffalo, NY 14203, USA
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Frequently asked questions about traveling from Buffalo, NY to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Buffalo to St. Louis?
The cheapest bus tickets from Buffalo to St. Louis start from $111. The average price for this route is around $173. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Buffalo to St. Louis?
The average bus trip duration from Buffalo to St. Louis is 1d 10h, covering a distance of 668 miles (1077 km). The quickest bus can get you there in 23h 30m and is operated by Greyhound.
Which bus companies service the Buffalo to St. Louis route?
What is the earliest and latest departure time for the bus from Buffalo to St. Louis?
The earliest bus departs from Buffalo to St. Louis at 7:55am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from Buffalo to St. Louis?
A bus trip from Buffalo to St. Louis generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Buffalo to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Buffalo to St. Louis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Buffalo to St. Louis?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Buffalo to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to St. Louis was searched and found on Nov 26, 2025 with a price of $152To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to St. Louis, as early as possible.
You can expect to pay from $152 to $342 for a bus ticket from Buffalo, NY to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $342 which is on 2025-11-30.
What's the cheapest way to go from Buffalo, NY to St. Louis?
The bus is the cheapest travel choice for this destination
