Next departures for Memphis to St. Louis on November 20
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Bus
Memphis Bus Station
Gateway Station
CheapestFastest
Next departures for Memphis to St. Louis on November 21
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Memphis Bus Station
Gateway Station
Cheapest
Bus
Memphis Bus Station
Gateway Station
Fastest
Next departures for Memphis to St. Louis on November 22
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Memphis Bus Station
Gateway Station
Cheapest
Bus
Memphis Bus Station
Gateway Station
Fastest
Next departures for Memphis to St. Louis on November 25
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Memphis Bus Station
Gateway Station
Cheapest
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Memphis Bus Station
Gateway Station
Fastest
Last refresh of the prices: Today at 10:28 AM CST.
Compare 2 ways to go from Memphis to St. Louis
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 5 hours 15 minutes and with fares starting at just $42, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Memphis St. Louis recent customer reviews
Frequently asked questions about traveling from Memphis, TN to St. Louis by bus
How far is Memphis from St. Louis?
The distance separating Memphis and St. Louis is 241 miles (388 km).
What are the departure and arrival stations when taking the bus from Memphis to St. Louis?
Buses traveling from Memphis to St. Louis leave from Airways Transit Center and arrive at Gateway Station.
What are the best sights and things to do in St. Louis?
Once in St. Louis, you can start exploring the city and discover its surroundings. The top sights and things to do are The Magic House, Lumière Place, Missouri Botanical Garden, Anheuser-Busch Brewery and Scott Joplin House State Historic Site.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$65
11/18
$48
Today
$48
11/20
$51
11/21
$56
11/22
$54
11/23
No data
11/24
$57
The cheapest trip from Memphis, TN to St. Louis was searched and found on Nov 18, 2025 with a price of $48
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Memphis, TN to St. Louis, as early as possible.
You can expect to pay from $48 to $80 for a bus ticket from Memphis, TN to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $51 which is on 2025-11-20.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Memphis, TN to St. Louis?
The bus is the cheapest travel choice for this destination