Based on 81 reviews, the company was rated 4 stars on Busbud. Travelers were especially satisfied with the departure location and the cleanliness but often complained with the wifi. Pluss Chile ticket prices on this trip start at $36
Based on 13 reviews, the company was rated 3.6 stars on Busbud. Travelers were especially satisfied with the seats and the temperature but often complained with the timeliness. Pullman San Andres ticket prices on this trip start at $41
Based on 125 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the staff and the ticket access but often complained with the wifi. Cikbus Elité ticket prices on this trip start at $27
Based on 54 reviews, the company was rated 4.2 stars on Busbud. Travelers were especially satisfied with the ticket access and the seats but often complained with the wifi. Buses Andimar ticket prices on this trip start at $34
Based on 3 reviews, the company was rated 4.3 stars on Busbud. Travelers were especially satisfied with the staff and the timeliness but often complained with the wifi. Clikbus ticket prices on this trip start at $31
Frequently asked questions about traveling from Antofagasta to Santiago, CL by bus
What is the distance between Antofagasta and Santiago?
About 677 miles (1091 km) separate Antofagasta and Santiago.
What are the departure and arrival stations when taking the bus from Antofagasta to Santiago?
If you're headed to Santiago from Antofagasta, chances are that your bus will leave from Terminal Antofagasta and arrive at San Borja. These are the most popular departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in Santiago?
Once in Santiago, you can start exploring the city and discover its surroundings. The top sights and things to do are El Biógrafo, Museo de la Memoria y los Derechos Humanos, Parque Forestal, Casablanca Valley Wine Tasting and Cajon del Maipo.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
$32
11/20
$33
Today
$33
11/22
$32
11/23
$33
11/24
$26
11/25
$26
11/26
$26
The cheapest trip from Antofagasta to Santiago, CL was searched and found on Nov 26, 2025 with a price of $26
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago, CL, as early as possible.
You can expect to pay from $26 to $65 for a bus ticket from Antofagasta to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $26 which is on 2025-11-26.
Usually Pullman San Andres, Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Antofagasta to Santiago, CL was searched and found on Nov 26, 2025 with a price of $26
