Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Antofagasta | Terminal de Buses San Borja - San Francisco de Borja | Cheapest | ||||
| Bus | Terminal Antofagasta | Terminal de Buses San Borja - San Francisco de Borja | Fastest | ||||
| Bus | Terminal Antofagasta | Terminal de Buses San Borja - San Francisco de Borja | No tags | ||||
 | Bus | Terminal Antofagasta | San Borja | No tags | ||||
 | Bus | Terminal Carlos Oviedo Cavada | San Borja | No tags |
Last refresh of the prices: Yesterday at 6:21 PM -03.
Get from Antofagasta to Santiago
The journey takes about 18 hours 20 minutes, and with fares starting at just $39, it presents an excellent value for a comfortable ride.
Where are the popular stops in Antofagasta and Santiago?
Stops in Antofagasta
- A
Av. Pedro Aguirre Cerda, 253
Av. Pedro Aguirre Cerda 253, Antofagasta, Región de Antofagasta, Chile - BTERMINAL ANTOFAGASTA, Av. Pedro Aguirre Cerda N° 5750, Antofagasta, Chile
- C
Terminal Flota Barrios
Capitán Carlos Condell 2764, Antofagasta, Región de Antofagasta, Chile - D
Terminal Pullman Bus
Av. Pedro Aguirre Cerda 8729, Antofagasta, Región de Antofagasta, Chile - E
Terminal Buses Camus
Av. Radomiro Tomic 7421 , Antofagasta, Región de Antofagasta, Chile - F
Terminal Tur Bus
Almirante Juan José Latorre 2751, Antofagasta, Región de Antofagasta, Chile
Stops in Santiago
- A
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - BSantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Santiago
Juan Esteban Montero 5688, Las Condes, Las Condes, Región Metropolitana, Chile
Compare bus companies
Frequently asked questions about travelling from Antofagasta to Santiago, CL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Antofagasta to Santiago?
The cheapest bus tickets from Antofagasta to Santiago start from $39. The average price for this route is around $69. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Antofagasta to Santiago?
The average bus travel time from Antofagasta to Santiago is 18h 20m, covering a distance of 1095 km. The quickest bus can get you there in 17h and is operated by Pullman San Andres.
Which bus companies service the Antofagasta to Santiago route?
Several major bus companies operate on this route with 49 buses available per day, including services from Pluss Chile, Pullman San Andres, Cikbus Elité, Buses Andimar, Clikbus.
What are the earliest and latest departure times for the bus from Antofagasta to Santiago?
The earliest bus departs from Antofagasta to Santiago at 12:05am. And the latest bus departs at 11:55pm.
What are the CO₂ emissions for the bus trip from Antofagasta to Santiago?
A bus trip from Antofagasta to Santiago generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Antofagasta to Santiago?
According to Busbud customers, the highest-rated bus company on this route is Clikbus, with an average rating of 4.3 out of 5 stars based on 3 reviews.
Which bus company has the best Wi-Fi from Antofagasta to Santiago?
Based on Busbud reviews, the bus company Pluss Chile has the highest Wi-Fi rating with a score of 1.6.
Which bus company has the best on-time performance from Antofagasta to Santiago?
According to Busbud traveller reviews, the most punctual bus company on this route is Clikbus, with a punctuality rating of 5.0 out of 5 stars.
Which bus company has the cleanest buses from Antofagasta to Santiago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Pluss Chile, with a cleanliness rating of 4.6 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Antofagasta to Santiago, CL was searched and found on Dec 3, 2025 with a price of $37To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago, CL, as early as possible.
You can expect to pay from $37 to $94 for a bus ticket from Antofagasta to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $37 which is on 2025-12-03.
Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
