How much is the bus ticket from San Luis Obispo to Santa Clara?

The cheapest bus tickets from San Luis Obispo to Santa Clara start from $109. The average price for this route is around $109. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from San Luis Obispo to Santa Clara?

The average bus travel time from San Luis Obispo to Santa Clara is 8h 15m, covering a distance of 308 km. The quickest bus can get you there in 4h 45m and is operated by Amtrak .

Which bus companies service the San Luis Obispo to Santa Clara route?

Several major bus companies operate on this route with 2 buses available per day.

What are the earliest and latest departure times for the bus from San Luis Obispo to Santa Clara?

The earliest bus departs from San Luis Obispo to Santa Clara at 6:50pm. And the latest bus departs at 7:25pm.

What are the CO₂ emissions for the bus trip from San Luis Obispo to Santa Clara?

A bus trip from San Luis Obispo to Santa Clara generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Bus San Luis Obispo to Santa Clara from $77 | Refundable Tickets

Next departures

Next departures for San Luis Obispo to Santa Clara on November 29
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
3:40pm	Cal Poly Vista Grande Dining Complex	7h 20m	11:00pm	Santa Ana Regional Transportation Center	Cheapest
4:00am	AMTRAK Station	7h	11:00am	Santa Ana Regional Transportation Center	Fastest
9:10am	Cal Poly Vista Grande Dining Complex	12h 29m	9:39pm	Great America Station	No tags
9:00am	AMTRAK Station	12h 39m	9:39pm	Great America Station	No tags
9:10am	Cal Poly Vista Grande Dining Complex	12h 38m	9:48pm	Santa Clara Transit Center	No tags

Last refresh of the prices: Yesterday at 10:29 PM PST.

Compare 2 ways to go from San Luis Obispo to Santa Clara

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Santa Clara. The journey takes about 6 hours 49 minutes, and with fares starting at just $71, it presents an excellent value for a comfortable ride.

3train per day

6h 49mAverage Duration

308 kmDistance

28kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$109 - $109	Average Duration8h 15m	CO₂ emissions 8kg CO₂e
Train	Average Price$71 - $151	Average Duration6h 49m	CO₂ emissions 28kg CO₂e

Compare bus companies

Amtrak

4/55,608 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5608 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $81

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from San Luis Obispo to Santa Clara, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from San Luis Obispo to Santa Clara?
The cheapest bus tickets from San Luis Obispo to Santa Clara start from $109. The average price for this route is around $109. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Luis Obispo to Santa Clara?
The average bus travel time from San Luis Obispo to Santa Clara is 8h 15m, covering a distance of 308 km. The quickest bus can get you there in 4h 45m and is operated by Amtrak.
Which bus companies service the San Luis Obispo to Santa Clara route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from San Luis Obispo to Santa Clara?
The earliest bus departs from San Luis Obispo to Santa Clara at 6:50pm. And the latest bus departs at 7:25pm.
What are the CO₂ emissions for the bus trip from San Luis Obispo to Santa Clara?
A bus trip from San Luis Obispo to Santa Clara generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-25

$77

11-26

No data

Today

$77

11-28

$77

11-29

$77

11-30

No data

12-01

$77

12-02

No data

The cheapest trip from San Luis Obispo to Santa Clara, US was searched and found on Nov 25, 2025 with a price of $77

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to Santa Clara, US, as early as possible.

You can expect to pay from $77 to $157 for a bus ticket from San Luis Obispo to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at $77 which is on 2025-11-28.