What is the distance between San Luis Obispo and Santa Clara?

The distance between San Luis Obispo and Santa Clara is around 264 km (164 miles).

Bus San Luis Obispo to Santa Clara from $77 | Refundable Tickets

Next departures

Next departures for San Luis Obispo to Santa Clara on November 29
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
3:40pm	Cal Poly Vista Grande Dining Complex	7h 20m	11:00pm	Santa Ana Regional Transportation Center	Cheapest
4:00am	AMTRAK Station	7h	11:00am	Santa Ana Regional Transportation Center	Fastest
9:10am	Cal Poly Vista Grande Dining Complex	12h 29m	9:39pm	Great America Station	No tags
9:00am	AMTRAK Station	12h 39m	9:39pm	Great America Station	No tags
9:10am	Cal Poly Vista Grande Dining Complex	12h 38m	9:48pm	Santa Clara Transit Center	No tags

Last refresh of the prices: Today at 10:29 PM PST.

Compare 2 ways to go from San Luis Obispo to Santa Clara

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Santa Clara. The journey takes about 6 hours 49 minutes, and with fares starting at just $71, it presents an excellent value for a comfortable ride.

3train per day

6h 49mAverage Duration

308 kmDistance

28kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$109 - $109	Average Duration8h 15m	CO₂ emissions 8kg CO₂e
Train	Average Price$71 - $151	Average Duration6h 49m	CO₂ emissions 28kg CO₂e

Compare bus companies

Amtrak

4/55,608 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5608 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $81

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from San Luis Obispo to Santa Clara, US by bus

What is the distance between San Luis Obispo and Santa Clara?
The distance between San Luis Obispo and Santa Clara is around 264 km (164 miles).

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-24

$93

11-25

$77

Today

No data

11-27

$77

11-28

$77

11-29

$77

11-30

No data

12-01

$77

The cheapest trip from San Luis Obispo to Santa Clara, US was searched and found on Nov 25, 2025 with a price of $77

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to Santa Clara, US, as early as possible.

You can expect to pay from $77 to $157 for a bus ticket from San Luis Obispo to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at $77 which is on 2025-11-27.