What is the distance between San Luis Obispo and Santa Clara?

About 164 miles (264 km) separate San Luis Obispo and Santa Clara.

Bus San Luis Obispo to Santa Clara from $53 | Refundable Tickets

Previously seen trips

Next departures for San Luis Obispo to Santa Clara on November 23
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	7:15pm	Cal Poly Vista Grande Dining Complex	8h 15m	3:30am	Santa Ana Regional Transportation Center	No tags
Bus	7:25pm	AMTRAK Station	8h 5m	3:30am	Santa Ana Regional Transportation Center	No tags
Bus	6:50pm	Cal Poly Vista Grande Dining Complex	8h 40m	3:30am	Santa Ana Regional Transportation Center	No tags
Bus	7:00pm	AMTRAK Station	8h 30m	3:30am	Santa Ana Regional Transportation Center	No tags
Bus	7:15pm	Cal Poly Vista Grande Dining Complex	8h 15m	3:30am	Santa Ana Regional Transportation Center	No tags

Compare 2 ways to go from San Luis Obispo to Santa Clara

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Santa Clara. The journey takes about 6 hours 49 minutes and with fares starting at just $49, it presents an excellent value for a comfortable ride.

2train per day

6h 49mAverage Duration

191 milesDistance

28kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$76 - $80	Average Duration8h 15m	CO₂ emissions 8kg CO₂e
Train	Average Price$49 - $110	Average Duration6h 49m	CO₂ emissions 28kg CO₂e

Compare bus companies

Amtrak

4/55,599 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5599 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $57

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from San Luis Obispo to Santa Clara, US by bus

What is the distance between San Luis Obispo and Santa Clara?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/20

$53

11/21

$53

Today

$53

11/23

$64

11/24

$64

11/25

$53

11/26

No data

11/27

$53

The cheapest trip from San Luis Obispo to Santa Clara, US was searched and found on Nov 20, 2025 with a price of $53

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to Santa Clara, US, as early as possible.

You can expect to pay from $53 to $107 for a bus ticket from San Luis Obispo to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at $53 which is on 2025-11-25.