Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Cal Poly Vista Grande Dining Complex | Santa Ana Regional Transportation Center | Cheapest | |||||
| AMTRAK Station | Santa Ana Regional Transportation Center | Fastest | |||||
| Cal Poly Vista Grande Dining Complex | Great America Station | No tags | |||||
| AMTRAK Station | Great America Station | No tags | |||||
| Cal Poly Vista Grande Dining Complex | Santa Clara Transit Center | No tags |
Last refresh of the prices: Yesterday at 22:29 PST.
Compare 2 ways to travel from San Luis Obispo to Santa Clara
Among the sustainable travel choices, the train stands out as a good way to reach Santa Clara. The journey takes about 6 hours 49 minutes and with fares starting at just £38, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 5608 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the Wi-Fi. Amtrak ticket prices on this trip start at £44
Frequently asked questions about travelling by bus from San Luis Obispo to Santa Clara, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from San Luis Obispo to Santa Clara?
The cheapest coach tickets from San Luis Obispo to Santa Clara start from £59. The average price for this route is around £59. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from San Luis Obispo to Santa Clara?
The average bus journey time from San Luis Obispo to Santa Clara is 8h 15m, covering a distance of 191 miles. The fastest bus can take you there in 4h 45m and is operated by Amtrak.
Which bus companies service the San Luis Obispo to Santa Clara route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from San Luis Obispo to Santa Clara?
The earliest bus departs from San Luis Obispo to Santa Clara at 18:50. And the latest bus departs at 19:25.
What are the CO₂ emissions for the bus trip from San Luis Obispo to Santa Clara?
A bus journey from San Luis Obispo to Santa Clara produces an estimated 8 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Luis Obispo to Santa Clara, US was searched and found on 25 Nov 2025 with a price of £41To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to Santa Clara, US as early as possible.
You can expect to pay from £41 to £85 for a bus ticket from San Luis Obispo to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at £41, which is on 2025-11-28.
