Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Ana Regional Transportation Center | Cal Poly Vista Grande Dining Complex | No tags | ||||
| Bus | Santa Ana Regional Transportation Center | AMTRAK Station | No tags | ||||
| Bus | Santa Ana Regional Transportation Center | Cal Poly Vista Grande Dining Complex | No tags | ||||
| Bus | Santa Ana Regional Transportation Center | AMTRAK Station | No tags | ||||
| Bus | Santa Ana Regional Transportation Center | Cal Poly Vista Grande Dining Complex | No tags |
Compare 2 ways to go from Santa Clara to San Luis Obispo
Among the sustainable travel choices, the train stands out as the good way to reach San Luis Obispo. The journey takes about 6 hours 51 minutes and with fares starting at just $49, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 5607 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $76
Frequently asked questions about traveling from Santa Clara, US to San Luis Obispo by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Clara, US to San Luis Obispo was searched and found on Nov 23, 2025 with a price of $72To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Clara, US to San Luis Obispo, as early as possible.
You can expect to pay from $72 to $76 for a bus ticket from Santa Clara, US to San Luis Obispo based on the last 2 days. You can expect to find the cheapest price for the trip at $74 which is on 2025-11-29.
