Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Ana Regional Transportation Center | Cal Poly Vista Grande Dining Complex | No tags | ||||
| Bus | Santa Ana Regional Transportation Center | AMTRAK Station | No tags | ||||
| Bus | Santa Ana Regional Transportation Center | Cal Poly Vista Grande Dining Complex | No tags | ||||
| Bus | Santa Ana Regional Transportation Center | AMTRAK Station | No tags | ||||
| Bus | Santa Ana Regional Transportation Center | Cal Poly Vista Grande Dining Complex | No tags |
Compare 2 ways to go from Santa Clara to San Luis Obispo
Among the sustainable travel choices, the train stands out as the good way to reach San Luis Obispo. The journey takes about 6 hours 51 minutes and with fares starting at just $49, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 5614 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $76
Frequently asked questions about traveling from Santa Clara, US to San Luis Obispo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Clara to San Luis Obispo?
The cheapest bus tickets from Santa Clara to San Luis Obispo start from $76. The average price for this route is around $76. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Clara to San Luis Obispo?
The average bus trip duration from Santa Clara to San Luis Obispo is 10h 45m, covering a distance of 192 miles (309 km). The quickest bus can get you there in 10h 35m and is operated by Amtrak.
Which bus companies service the Santa Clara to San Luis Obispo route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Santa Clara to San Luis Obispo?
The earliest bus departs from Santa Clara to San Luis Obispo at 10:50pm. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Santa Clara to San Luis Obispo?
A bus trip from Santa Clara to San Luis Obispo generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Clara, US to San Luis Obispo was searched and found on Nov 29, 2025 with a price of $74To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Clara, US to San Luis Obispo, as early as possible.
