Bus Tickets from San Luis Obispo to San Diego, CA, US
Next departures
Next departures for San Luis Obispo to San Diego on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
AMTRAK Station
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
AMTRAK Station
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
AMTRAK Station
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Last refresh of the prices: Yesterday at 6:24 PM PST.
Compare 2 ways to go from San Luis Obispo to San Diego
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 8 hours 44 minutes, and with fares starting at just $93, it presents an excellent value for a comfortable ride.
Based on 5601 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $104
Amtrak San Luis Obispo San Diego recent customer reviews
Based on 11416 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $46
Frequently asked questions about travelling from San Luis Obispo to San Diego, CA, US by bus
What is the distance between San Luis Obispo and San Diego?
San Luis Obispo and San Diego are 426 km (264 miles) apart.
What are the departure and arrival locations for buses traveling from San Luis Obispo to San Diego?
Buses departing from AMTRAK Station in San Luis Obispo will take you to Mission Valley Sheraton in San Diego.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-21
$99
11-22
$99
Today
$99
11-24
$99
11-25
$99
11-26
$99
11-27
$99
11-28
$99
The cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on Nov 21, 2025 with a price of $99
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, CA, US, as early as possible.
You can expect to pay from $99 to $198 for a bus ticket from San Luis Obispo to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $99 which is on 2025-11-24.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on Nov 21, 2025 with a price of $99
