Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Ana Bus Station | San Diego (Old Town-FlixBus) | Cheapest | ||||
| Bus | Santa Ana Bus Station | UCSD Health La Jolla Station | Fastest | ||||
| Bus | Anaheim Regional Transportation Intermodal Center | San Diego (Old Town-FlixBus) | No tags | ||||
 | Bus | Anaheim Regional Transportation Intermodal Center | Greyhound Bus Stop | No tags | ||||
 | Bus | Santa Ana E Santa Ana Blvd | Cross Border Xpress CBX (USA) | No tags |
Last refresh of the prices: Today at 6:25 AM PST.
Get from Santa Ana to San Diego
The journey takes about 2 hours 10 minutes, and with fares starting at just $28, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santa Ana and San Diego?
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
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Frequently asked questions about travelling from Santa Ana, US to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Ana to San Diego?
The cheapest bus tickets from Santa Ana to San Diego start from $28. The average price for this route is around $64. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Ana to San Diego?
The average bus travel time from Santa Ana to San Diego is 2h 10m, covering a distance of 158 km. The quickest bus can get you there in 1h 10m and is operated by FlixBus.
Which bus companies service the Santa Ana to San Diego route?
Several major bus companies operate on this route with 23 buses available per day, including services from Los Limousines, FlixBus, Greyhound.
What are the earliest and latest departure times for the bus from Santa Ana to San Diego?
The earliest bus departs from Santa Ana to San Diego at 5:55am. And the latest bus departs at 10:45pm.
What are the CO₂ emissions for the bus trip from Santa Ana to San Diego?
A bus trip from Santa Ana to San Diego generates an estimated 4 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Santa Ana to San Diego?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Santa Ana to San Diego?
Based on Busbud reviews, the bus company Los Limousines has the highest Wi-Fi rating with a score of 2.8.
Which bus company has the best on-time performance from Santa Ana to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Santa Ana to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Ana, US to San Diego, CA, US was searched and found on Dec 2, 2025 with a price of $22To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to San Diego, CA, US, as early as possible.
You can expect to pay from $22 to $70 for a bus ticket from Santa Ana, US to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $22 which is on 2025-12-02.
Usually Los Limousines, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
