Find coaches from San Luis Obispo to San Diego, CA, US

Next departures

Next departures from San Luis Obispo to San Diego on 24 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Amtrak
Cal Poly Vista Grande Dining Complex
Santa Fe DepotCheapest
FlixBus
San Luis Obispo
UCSD Health La Jolla StationFastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus StopNo tags
FlixBus
San Luis Obispo
Downtown SD (Seaport)No tags
Amtrak
Cal Poly Vista Grande Dining Complex
Santa Fe DepotNo tags

Last refresh of the prices: Yesterday at 21:48 PST.

Compare 2 ways to travel from San Luis Obispo to San Diego

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 8 hours 44 minutes and with fares starting at just £51, it presents an excellent value for a comfortable ride.

5train per day
8h 44mAverage duration
267 milesDistance
39kgCO₂ emissions
Average price£25 - £96Average duration10h
11kg CO₂e
Average price£51 - £102Average duration8h 44m
39kg CO₂e

Frequently asked questions about travelling by bus from San Luis Obispo to San Diego, CA, US

  1. How far is San Diego from San Luis Obispo by coach?

    The journey from San Luis Obispo to San Diego by coach covers an approximate distance of 264 miles (426 km).

  2. What is the best way to go from San Luis Obispo to San Diego without flying?

    To travel from San Luis Obispo to San Diego without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
21/11
£54
22/11
£54
Today
£54
24/11
£54
25/11
£54
26/11
£54
27/11
£54
28/11
£54
busbud logoThe cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on 21 Nov 2025 with a price of £54

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, CA, US as early as possible.

You can expect to pay from £54 to £108 for a bus ticket from San Luis Obispo to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at £54, which is on 2025-11-24.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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