How far is San Diego from San Luis Obispo by coach?

The journey from San Luis Obispo to San Diego by coach covers an approximate distance of 264 miles (426 km).

What is the best way to go from San Luis Obispo to San Diego without flying?

To travel from San Luis Obispo to San Diego without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Bus San Luis Obispo to San Diego from £35 | Refundable Tickets

Next departures

Next departures from San Luis Obispo to San Diego on 26 November
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	14:40	Cal Poly Vista Grande Dining Complex	10h 24m	01:04	Santa Fe Depot	Cheapest
	12:55	San Luis Obispo	8h 50m	21:45	UCSD Health La Jolla Station	Fastest
FlixBus + Greyhound Lines, Inc.	12:55	San Luis Obispo	10h 55m	23:50	Greyhound Bus Stop	No tags
	12:55	San Luis Obispo	9h 20m	22:15	Downtown SD (Seaport)	No tags
	14:40	Cal Poly Vista Grande Dining Complex	10h 24m	01:04	Santa Fe Depot	No tags

Next departures from San Luis Obispo to San Diego on 27 November
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	15:40	Cal Poly Vista Grande Dining Complex	9h 24m	01:04	Santa Fe Depot	Cheapest
	12:55	San Luis Obispo	8h 50m	21:45	UCSD Health La Jolla Station	Fastest
FlixBus + Greyhound Lines, Inc.	12:55	San Luis Obispo	10h 55m	23:50	Greyhound Bus Stop	No tags
	12:55	San Luis Obispo	9h 20m	22:15	Downtown SD (Seaport)	No tags
	03:45	Cal Poly Vista Grande Dining Complex	9h 22m	13:07	Santa Fe Depot	No tags

Next departures from San Luis Obispo to San Diego on 28 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
15:40	Cal Poly Vista Grande Dining Complex	9h 24m	01:04	Santa Fe Depot	Cheapest
04:00	AMTRAK Station	8h 53m	12:53	Old Town San Diego	Fastest
03:45	Cal Poly Vista Grande Dining Complex	9h 22m	13:07	Santa Fe Depot	No tags
10:15	Cal Poly Vista Grande Dining Complex	9h 49m	20:04	Santa Fe Depot	No tags
10:15	Cal Poly Vista Grande Dining Complex	9h 49m	20:04	Santa Fe Depot	No tags

Next departures from San Luis Obispo to San Diego on 29 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
15:40	Cal Poly Vista Grande Dining Complex	9h 24m	01:04	Santa Fe Depot	Cheapest
04:00	AMTRAK Station	8h 53m	12:53	Old Town San Diego	Fastest
03:45	Cal Poly Vista Grande Dining Complex	9h 22m	13:07	Santa Fe Depot	No tags
10:15	Cal Poly Vista Grande Dining Complex	9h 49m	20:04	Santa Fe Depot	No tags
15:40	Cal Poly Vista Grande Dining Complex	9h 24m	01:04	Santa Fe Depot	No tags

Next departures from San Luis Obispo to San Diego on 30 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
14:40	Cal Poly Vista Grande Dining Complex	10h 24m	01:04	Santa Fe Depot	Cheapest
04:00	AMTRAK Station	8h 53m	12:53	Old Town San Diego	Fastest
03:45	Cal Poly Vista Grande Dining Complex	9h 22m	13:07	Santa Fe Depot	No tags
14:40	Cal Poly Vista Grande Dining Complex	10h 24m	01:04	Santa Fe Depot	No tags
03:45	Cal Poly Vista Grande Dining Complex	9h 8m	12:53	Old Town San Diego	No tags

Next departures from San Luis Obispo to San Diego on 1 December
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	15:40	Cal Poly Vista Grande Dining Complex	9h 24m	01:04	Santa Fe Depot	Cheapest
	12:55	San Luis Obispo	8h 50m	21:45	UCSD Health La Jolla Station	Fastest
FlixBus + Greyhound Lines, Inc.	12:55	San Luis Obispo	10h 55m	23:50	Greyhound Bus Stop	No tags
	12:55	San Luis Obispo	9h 20m	22:15	Downtown SD (Seaport)	No tags
	03:45	Cal Poly Vista Grande Dining Complex	9h 22m	13:07	Santa Fe Depot	No tags

Next departures from San Luis Obispo to San Diego on 2 December
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	15:40	Cal Poly Vista Grande Dining Complex	9h 24m	01:04	Santa Fe Depot	Cheapest
	12:55	San Luis Obispo	8h 50m	21:45	UCSD Health La Jolla Station	Fastest
FlixBus + Greyhound Lines, Inc.	12:55	San Luis Obispo	10h 55m	23:50	Greyhound Bus Stop	No tags
	12:55	San Luis Obispo	9h 20m	22:15	Downtown SD (Seaport)	No tags
	03:45	Cal Poly Vista Grande Dining Complex	9h 22m	13:07	Santa Fe Depot	No tags

Next departures from San Luis Obispo to San Diego on 3 December
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	12:55	San Luis Obispo	8h 50m	21:45	UCSD Health La Jolla Station	CheapestFastest
FlixBus + Greyhound Lines, Inc.	12:55	San Luis Obispo	10h 55m	23:50	Greyhound Bus Stop	No tags
	12:55	San Luis Obispo	9h 20m	22:15	Downtown SD (Seaport)	No tags
	03:45	Cal Poly Vista Grande Dining Complex	9h 22m	13:07	Santa Fe Depot	No tags
	03:45	Cal Poly Vista Grande Dining Complex	9h 22m	13:07	Santa Fe Depot	No tags

Last refresh of the prices: Yesterday at 12:02 PST.

Compare 2 ways to travel from San Luis Obispo to San Diego

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 8 hours 44 minutes and with fares starting at just £51, it presents an excellent value for a comfortable ride.

5train per day

8h 44mAverage duration

267 milesDistance

39kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average price£27 - £102	Average duration10h 10m	CO₂ emissions 11kg CO₂e
Train	Average price£51 - £101	Average duration8h 44m	CO₂ emissions 39kg CO₂e

Where are the popular stops in San Luis Obispo and San Diego?

Stops in San Luis Obispo

A
AMTRAK Station
1730 Santa Rosa St, San Luis Obispo, CA 93401, USA
Visit page
B
San Luis Obispo Bus Stop
1460 Calle Joaquin, San Luis Obispo, CA 93405, USA

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Compare bus companies

Amtrak

4/55,607 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

WiFi3.6

FlixBus

3.5/511,447 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

WiFi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling by bus from San Luis Obispo to San Diego, CA, US

How far is San Diego from San Luis Obispo by coach?
The journey from San Luis Obispo to San Diego by coach covers an approximate distance of 264 miles (426 km).
What is the best way to go from San Luis Obispo to San Diego without flying?
To travel from San Luis Obispo to San Diego without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

24/11

£53

25/11

£120

Today

£53

27/11

£53

28/11

£53

29/11

£53

30/11

£53

01/12

£53

The cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on 24 Nov 2025 with a price of £53

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, CA, US as early as possible.

You can expect to pay from £53 to £124 for a bus ticket from San Luis Obispo to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at £53, which is on 2025-11-27.