Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Fe Depot | AMTRAK Station | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Greyhound Bus Stop | San Luis Obispo | Fastest |
Last refresh of the prices: Yesterday at 8:02 PM PST.
Compare 2 ways to go from San Diego to San Luis Obispo
Among the sustainable travel choices, the train stands out as a good way to reach San Luis Obispo. The journey takes about 8 hours 47 minutes, and with fares starting at just $93, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and San Luis Obispo?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in San Luis Obispo
- A1730 Santa Rosa St, San Luis Obispo, CA 93401, USA
- B
San Luis Obispo Bus Stop
1460 Calle Joaquin, San Luis Obispo, CA 93405, USA
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Frequently asked questions about travelling from San Diego, CA, US to San Luis Obispo by bus
What is the travel distance from San Diego to San Luis Obispo?
San Diego and San Luis Obispo are 426 km (264 miles) apart.
What are the departure and arrival locations for buses traveling from San Diego to San Luis Obispo?
Buses departing from Mission Valley Sheraton in San Diego will take you to AMTRAK Station in San Luis Obispo.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to San Luis Obispo was searched and found on Nov 18, 2025 with a price of $122To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to San Luis Obispo, as early as possible.
You can expect to pay from $122 to $126 for a bus ticket from San Diego, CA, US to San Luis Obispo based on the last 2 days. You can expect to find the cheapest price for the trip at $122 which is on 2025-11-21.
Top travelled bus routes
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Popular bus departures from San Diego
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