Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Greyhound Bus Stop | San Luis Obispo | CheapestFastest |
Last refresh of the prices: Yesterday at 18:18 PST.
Compare 2 ways to travel from San Diego to San Luis Obispo
Among the sustainable travel choices, the train stands out as a good way to reach San Luis Obispo. The journey takes about 8 hours 47 minutes and with fares starting at just £51, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and San Luis Obispo?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in San Luis Obispo
- A1730 Santa Rosa St, San Luis Obispo, CA 93401, USA
- B
San Luis Obispo Bus Stop
1460 Calle Joaquin, San Luis Obispo, CA 93405, USA
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Frequently asked questions about travelling by bus from San Diego, CA, US to San Luis Obispo
How far is San Luis Obispo from San Diego by coach?
The journey from San Diego to San Luis Obispo by coach covers an approximate distance of 264 miles (426 km).
Is there a way to reach San Luis Obispo from San Diego without flying?
To travel from San Diego to San Luis Obispo without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to San Luis Obispo was searched and found on 21 Nov 2025 with a price of £66To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to San Luis Obispo as early as possible.
You can expect to pay from £66 to £69 for a bus ticket from San Diego, CA, US to San Luis Obispo based on the last 2 days. You can expect to find the cheapest price for the trip at £68, which is on 2025-11-24.
