Bus from Santiago, CL to Antofagasta: Tickets & Schedules

Next bus departures

Next departures for Santiago to Antofagasta on November 28
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Cikbus ElitéBus
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaCheapest
Cikbus ElitéBus
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaFastest
Cikbus ElitéBus
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaNo tags
Pluss ChileBus
San Borja
Terminal AntofagastaNo tags
Pullman San AndrésBus
San Borja
Terminal Carlos Oviedo CavadaNo tags

Last refresh of the prices: Yesterday at 10:31 PM -03.

Get from Santiago to Antofagasta

This route is served by bus only

The journey takes about 18 hours 40 minutes and with fares starting at just $27, it presents an excellent value for a comfortable ride.

47bus per day
18h 40mAverage Duration
679 milesDistance
27kgCO₂ emissions

Frequently asked questions about traveling from Santiago, CL to Antofagasta by bus

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/25
$36
11/26
$36
Today
$33
11/28
$26
11/29
$26
11/30
$33
12/01
$26
12/02
$26
busbud logoThe cheapest trip from Santiago, CL to Antofagasta was searched and found on Dec 2, 2025 with a price of $26

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Antofagasta, as early as possible.

You can expect to pay from $26 to $66 for a bus ticket from Santiago, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at $26 which is on 2025-12-02.

Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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