Bus from Santiago, CL to Antofagasta: Tickets & Schedules

Next bus departures

Next departures for Santiago to Antofagasta on November 28
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Cikbus ElitéBus
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaCheapest
Cikbus ElitéBus
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaFastest
Cikbus ElitéBus
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaNo tags
Pluss ChileBus
San Borja
Terminal AntofagastaNo tags
Pullman San AndrésBus
San Borja
Terminal Carlos Oviedo CavadaNo tags

Last refresh of the prices: Today at 7:53 AM -03.

Get from Santiago to Antofagasta

This route is served by bus only

The journey takes about 18 hours 40 minutes and with fares starting at just $27, it presents an excellent value for a comfortable ride.

47bus per day
18h 40mAverage Duration
679 milesDistance
27kgCO₂ emissions

Frequently asked questions about traveling from Santiago, CL to Antofagasta by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from Santiago to Antofagasta?

    The cheapest bus tickets from Santiago to Antofagasta start from $27. The average price for this route is around $48. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from Santiago to Antofagasta?

    The average bus trip duration from Santiago to Antofagasta is 18h 40m, covering a distance of 679 miles (1095 km). The quickest bus can get you there in 17h and is operated by Clikbus.

  3. Which bus companies service the Santiago to Antofagasta route?

    Several major bus companies operate on this route with 47 buses available per day, including services from Pluss Chile, Pullman San Andres, Cikbus Elité, Buses Andimar, Condor Bus, Buses Romani, Serena Mar, Buses Paravias, Clikbus.

  4. What is the earliest and latest departure time for the bus from Santiago to Antofagasta?

    The earliest bus departs from Santiago to Antofagasta at 6:15am. And the latest bus departs at 11:59pm.

  5. What are the CO₂ emissions for the bus trip from Santiago to Antofagasta?

    A bus trip from Santiago to Antofagasta generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

  6. What is the best bus company from Santiago to Antofagasta?

    According to Busbud customers, the highest-rated bus company on this route is Clikbus, with an average rating of 4.3 out of 5 stars based on 3 reviews.

  7. Which bus company has the best Wi-Fi from Santiago to Antofagasta?

    Based on reviews on Busbud, the bus company Buses Paravias has the best Wi-Fi rating with a score of 1.8.

  8. Which bus company has the most timely service from Santiago to Antofagasta?

    According to Busbud traveller reviews, the most timely bus company on this route is Clikbus, with a punctuality rating of 5.0 out of 5 stars.

  9. Which bus company has the cleanest buses from Santiago to Antofagasta?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Pluss Chile, with a cleanliness rating of 4.6 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/25
$36
11/26
$36
Today
$33
11/28
$26
11/29
$26
11/30
$33
12/01
$26
12/02
$32
busbud logoThe cheapest trip from Santiago, CL to Antofagasta was searched and found on Nov 28, 2025 with a price of $26

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Antofagasta, as early as possible.

You can expect to pay from $26 to $66 for a bus ticket from Santiago, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at $26 which is on 2025-11-28.

Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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