Bus Tickets from San Diego, CA, US to Greenville, SC

Previously seen trips

Next departures for San Diego to Greenville on October 22
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
San Diego (Old Town-FlixBus)
1116 Woodruff RdNo tags
FlixBus + Greyhound
San Diego (Old Town-FlixBus)
1116 Woodruff RdNo tags
Greyhound + FlixBus
UCSD Health La Jolla Station
1116 Woodruff RdNo tags
FlixBus + Greyhound
UCSD Health La Jolla Station
1116 Woodruff RdNo tags
Greyhound + FlixBus
San Diego (Old Town-FlixBus)
1116 Woodruff RdNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus San Diego, CA, US to Greenville, SC: Trip Overview

Average ticket price$211
Average bus trip duration2d 12h
Number of daily buses7
Earliest bus departure6:45am
Distance1995 miles (3217 km)
Latest bus departure7:35pm

San Diego to Greenville Bus

With Busbud, comparing and booking tickets for a bus from San Diego to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from San Diego to Greenville from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from San Diego, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip San Diego, CA, US - Greenville, SC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/20
No data
10/21
No data
Today
No data
10/23
No data
10/24
No data
10/25
$148
10/26
No data
10/27
No data
busbud logoThe cheapest trip from San Diego, CA, US to Greenville, SC was searched and found on Oct 25, 2025 with a price of $148

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Greenville, SC, as early as possible.

You can expect to pay from $148 to $148 for a bus ticket from San Diego, CA, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $148 which is on 2025-10-25.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Diego to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to Greenville, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Diego to Greenville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Greenville.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to San Diego, CA, US by bus?

Bus from Greenville, SC to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting San Diego

Buses Leaving from San Diego

Buses Going to San Diego

Popular Buses Connecting Greenville

Buses Leaving from Greenville

Buses Going to Greenville