Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Greyhound Bus Stop | 1116 Woodruff Rd | CheapestFastest |
Last refresh of the prices: Yesterday at 7:40 AM PST.
Get from San Diego to Greenville
The journey takes about 2 days, 11 hours 20 minutes, and with fares starting at just $195, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and Greenville?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
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Frequently asked questions about travelling from San Diego, CA, US to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Diego to Greenville?
The cheapest bus tickets from San Diego to Greenville start from $195. The average price for this route is around $399. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Diego to Greenville?
The average bus travel time from San Diego to Greenville is 2d 11h, covering a distance of 3216 km. The quickest bus can get you there in 2d 8h and is operated by Greyhound.
Which bus companies service the San Diego to Greenville route?
What are the earliest and latest departure times for the bus from San Diego to Greenville?
The earliest bus departs from San Diego to Greenville at 6:45am. And the latest bus departs at 7:35pm.
What are the CO₂ emissions for the bus trip from San Diego to Greenville?
A bus trip from San Diego to Greenville generates an estimated 80 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from San Diego to Greenville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from San Diego to Greenville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from San Diego to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Greenville, SC was searched and found on Jan 3, 2026 with a price of $253To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Greenville, SC, as early as possible.
