How much is the bus ticket from Prague to Brussels?

The cheapest bus tickets from Prague to Brussels start from $44. The average price for this route is around $71. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Prague to Brussels?

The average bus trip duration from Prague to Brussels is 18h 40m, covering a distance of 447 miles (720 km). The quickest bus can get you there in 12h and is operated by RegioJet .

Which bus companies service the Prague to Brussels route?

Several major bus companies operate on this route with 15 buses available per day, including services from FlixBus , BlaBlaCar Bus , RegioJet .

What is the earliest and latest departure time for the bus from Prague to Brussels?

The earliest bus departs from Prague to Brussels at 12:10am. And the latest bus departs at 11:05pm.

What are the CO₂ emissions for the bus trip from Prague to Brussels?

A bus trip from Prague to Brussels generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Prague to Brussels?

According to Busbud customers, the highest-rated bus company on this route is RegioJet , with an average rating of 4.1 out of 5 stars based on 1057 reviews.

Which bus company has the best Wi-Fi from Prague to Brussels?

Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.

Which bus company has the most timely service from Prague to Brussels?

According to Busbud traveller reviews, the most timely bus company on this route is RegioJet , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Prague to Brussels?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet , with a cleanliness rating of 4.3 out of 5 stars.

Bus Prague to Brussels from $44 | Refundable Tickets

Next bus departures

Next departures for Prague to Brussels on November 30
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	3:50am	Prague (Main Station - parking)	14h 15m	6:05pm	Brussels North Train Station	Cheapest
Bus	4:10am	Prague (Na Knížecí)	13h 55m	6:05pm	Brussels North Train Station	Fastest
Bus	7:00pm	Florenc	18h 30m	1:30pm	Brussels-South (Gare du Midi)	No tags
Bus	4:15pm	Prague (Central Bus Station Florenc)	16h	8:15am	Brussels Airport	No tags
Bus	5:00pm	Prague (Central Bus Station Florenc)	17h 50m	10:50am	Brussels Airport	No tags

Next departures for Prague to Brussels on December 2
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	Prague (Central Bus Station Florenc)	18h 20m	8:50am	Brussels North Train Station	Cheapest
Bus	6:00pm	Florenc	12h	6:00am	Brussels South (Gare du Midi)	Fastest
Bus	7:35am	Prague (Central Bus Station Florenc)	1d 1h	8:45am	Brussels Airport	No tags
Bus	10:00pm	Prague (Central Bus Station Florenc)	23h 15m	9:15pm	Brussels Airport	No tags
Bus	6:45pm	Prague (Main Railway Station)	1d 2h	9:15pm	Brussels Airport	No tags

Next departures for Prague to Brussels on December 4
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	7:00pm	Florenc	18h 30m	1:30pm	Brussels-South (Gare du Midi)	CheapestFastest

Last refresh of the prices: Yesterday at 10:33 PM CET.

Compare 2 ways to go from Prague to Brussels

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Brussels. The journey takes about 18 hours 40 minutes and with fares starting at just $44, it presents an excellent value for a comfortable ride.

15bus per day

18h 40mAverage Duration

447 milesDistance

18kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$44 - $255	Average Duration18h 40m	CO₂ emissions 18kg CO₂e
Train	Average Price$61 - $289	Average Duration15h 25m	CO₂ emissions 17kg CO₂e

Where are the popular stops in Prague and Brussels?

Stops in Prague

A
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
Visit page
B
PRG Airport
Aviatická, 161 08, Praha 6, Czechia
Visit page
C
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic
D
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
Visit page
E
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic
Visit page
F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Visit page

Stops in Brussels

A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium
Visit page
B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
Visit page
C
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
Visit page
D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium

Compare bus companies

FlixBus

3.5/511,473 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

BlaBlaCar Bus

3.5/511,172 reviews

Staff4.4

Timeliness3.6

Cleanliness4.3

Wifi2.6

RegioJet

4/51,057 reviews

Staff4.5

Timeliness3.9

Cleanliness4.4

Wifi3.8

BE bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Prague to Brussels by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Prague to Brussels?
The cheapest bus tickets from Prague to Brussels start from $44. The average price for this route is around $71. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Brussels?
The average bus trip duration from Prague to Brussels is 18h 40m, covering a distance of 447 miles (720 km). The quickest bus can get you there in 12h and is operated by RegioJet.
Which bus companies service the Prague to Brussels route?
Several major bus companies operate on this route with 15 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What is the earliest and latest departure time for the bus from Prague to Brussels?
The earliest bus departs from Prague to Brussels at 12:10am. And the latest bus departs at 11:05pm.
What are the CO₂ emissions for the bus trip from Prague to Brussels?
A bus trip from Prague to Brussels generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Prague to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1057 reviews.
Which bus company has the best Wi-Fi from Prague to Brussels?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Prague to Brussels?
According to Busbud traveller reviews, the most timely bus company on this route is RegioJet, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Prague to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.3 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/27

$81

11/28

$60

Today

$69

11/30

$71

12/01

No data

12/02

$46

12/03

No data

12/04

$62

The cheapest trip from Prague to Brussels was searched and found on Dec 2, 2025 with a price of $46

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.

You can expect to pay from $46 to $192 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $46 which is on 2025-12-02.