Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Chicago Des Moines recent customer reviews
Maybe it should be written in the details of the trip that we have to weigh our luggage.
Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Based on 20 reviews, the company was rated 4.2 stars on Busbud. Travelers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Burlington Trailways ticket prices on this trip start at $60
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Chicago to Des Moines by bus
What is the distance between Chicago and Des Moines?
The distance between the two cities is 308 miles (496 km).
What are the departure and arrival stations when taking the bus from Chicago to Des Moines?
If you're headed to Des Moines from Chicago, chances are that your bus will depart from Downtown Greyhound Station and arrive at Jefferson/Trailways Depot. These are the main departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/21
$156
11/22
$80
Today
$91
11/24
$80
11/25
$76
11/26
$71
11/27
$56
11/28
$61
The cheapest trip from Chicago to Des Moines was searched and found on Nov 27, 2025 with a price of $56
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Des Moines, as early as possible.
You can expect to pay from $56 to $156 for a bus ticket from Chicago to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at $56 which is on 2025-11-27.
The cheapest trip from Chicago to Des Moines was searched and found on Nov 27, 2025 with a price of $56
