Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Downtown LA (Flixbus Lot) | Cheapest | ||||
 | Bus | Des Moines | Los Angeles Union Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Lankershim/Magnolia - North Hollywood | No tags |
Last refresh of the prices: Today at 5:36 PM CST.
Get from Des Moines to Los Angeles
The journey takes about 1 day, 21 hours 45 minutes and with fares starting at just $184, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Los Angeles?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Los Angeles
- A571-581 Gayley Ave, Los Angeles, CA 90024, USA
- B
Ramirez Street bus stop
530 Ramirez St, Los Angeles, CA 90012, USA - C613 Maple Ave, Los Angeles, CA 90014, USA
- E
Downtown Westin Bonaventure
404 S Figueroa St, Los Angeles, CA 90071, USA - F
LAX Airport Holiday Inn
9901 S La Cienega Blvd, Los Angeles, CA 90045, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Des Moines to Los Angeles, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Los Angeles?
The cheapest bus tickets from Des Moines to Los Angeles start from $184. The average price for this route is around $231. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Los Angeles?
The average bus trip duration from Des Moines to Los Angeles is 1d 21h, covering a distance of 1434 miles (2312 km). The quickest bus can get you there in 1d 15h and is operated by Greyhound.
Which bus companies service the Des Moines to Los Angeles route?
Several major train operators operate on this route with 3 trains available per day.
What is the earliest and latest departure time for the bus from Des Moines to Los Angeles?
The earliest bus departs from Des Moines to Los Angeles at 5:30am. And the latest bus departs at 7:15pm.
What are the CO₂ emissions for the bus trip from Des Moines to Los Angeles?
A bus trip from Des Moines to Los Angeles generates an estimated 58 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Los Angeles, US was searched and found on Dec 23, 2025 with a price of $192To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Los Angeles, US, as early as possible.
You can expect to pay from $192 to $543 for a bus ticket from Des Moines to Los Angeles, US based on the last 2 days. You can expect to find the cheapest price for the trip at $192 which is on 2025-12-24.
