Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines | Lankershim/Magnolia - North Hollywood | Cheapest | ||||
| Bus | Des Moines | Los Angeles Union Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Downtown LA (Flixbus Lot) | No tags |
Last refresh of the prices: Last Saturday at 10:04 PM CST.
Get from Des Moines to Los Angeles
The journey takes about 1 day, 21 hours 45 minutes, and with fares starting at just $257, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Los Angeles?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Los Angeles
- A571-581 Gayley Ave, Los Angeles, CA 90024, USA
- B
Ramirez Street bus stop
530 Ramirez St, Los Angeles, CA 90012, USA - C613 Maple Ave, Los Angeles, CA 90014, USA
- E
Downtown Westin Bonaventure
404 S Figueroa St, Los Angeles, CA 90071, USA - F
LAX Airport Holiday Inn
9901 S La Cienega Blvd, Los Angeles, CA 90045, USA
Compare bus companies
Based on 87448 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $257
Frequently asked questions about travelling from Des Moines to Los Angeles, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Los Angeles?
The cheapest bus tickets from Des Moines to Los Angeles start from $257. The average price for this route is around $323. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Los Angeles?
The average bus travel time from Des Moines to Los Angeles is 1d 21h, covering a distance of 2312 km. The quickest bus can get you there in 1d 15h and is operated by Greyhound.
Which bus companies service the Des Moines to Los Angeles route?
Several major bus companies operate on this route with 3 buses available per day.
What are the earliest and latest departure times for the bus from Des Moines to Los Angeles?
The earliest bus departs from Des Moines to Los Angeles at 5:30am. And the latest bus departs at 7:15pm.
What are the CO₂ emissions for the bus trip from Des Moines to Los Angeles?
A bus trip from Des Moines to Los Angeles generates an estimated 58 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Los Angeles, US was searched and found on Dec 23, 2025 with a price of $270To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Los Angeles, US, as early as possible.
You can expect to pay from $270 to $514 for a bus ticket from Des Moines to Los Angeles, US based on the last 2 days. You can expect to find the cheapest price for the trip at $301 which is on 2025-12-28.
