Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Baytown, 6800 Thompson Rd | 1116 Woodruff Rd | Cheapest | ||||
 | Bus | Houston Lockwood, (TX - TBC Lockwood) | Greenville, (SC - Taqueria Guadalajara #3) | Fastest | ||||
 | Bus | Houston Bus Station | 1116 Woodruff Rd | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Houston Bus Station | 1116 Woodruff Rd | No tags | ||||
Valley Transit + Greyhound Lines, Inc. + FlixBus | Bus | Hillcroft Ave & Southwest Freeway | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Yesterday at 5:16 PM CST.
Compare 2 ways to travel from Houston to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 1 day, 3 hours 50 minutes and with fares starting at just R 1 821, it presents an excellent value for a comfortable ride.
Where are the popular stops in Houston and Greenville?
Stops in Houston
- A
Hillcroft Ave & Southwest Freeway
6590 Southwest Fwy, Houston, TX 77074, USA - B2121 Main St, Houston, TX 77002
- C
Harrisburg Greyhound Station
7000 Harrisburg Blvd, Houston, TX 77011, USA - D7011 Harrisburg Blvd, Houston, TX 77011, USA
- E
Clay St & Louisiana St
600-698 Clay St, Houston, TX 77002, USA - F
Lockwood Dr & Harvey Wilson Dr
820 Lockwood Dr, Houston, TX 77002, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
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Frequently asked questions about travelling from Houston, US to Greenville, SC by bus
How much does a bus ticket from Houston to Greenville cost?
The bus ticket price from Houston to Greenville starts at R 1 821. The best way to find cheap bus tickets from Houston to Greenville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Houston to Greenville?
The average travel time between Houston and Greenville is around 1d 3h, although the fastest bus will take about 15h 11m. This is the time it takes to travel the 1344 km that separates the two cities.
How many daily bus connections are there between Houston and Greenville?
The number of buses from Houston to Greenville can differ depending on the day of the week. On average, there are 21 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Houston to Greenville by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Houston to Greenville?
When taking the bus from Houston to Greenville, you can travel comfortably and safely with Greyhound, Tornado Bus, Amtrak.
What are the departure and arrival stations when taking the bus from Houston to Greenville?
Buses travelling between Houston and Greenville leave from Hillcroft Ave & Southwest Freeway or Downtown Greyhound Station and arrive at Guadalajara Supermarket Bus Stop, Greenville Bus Station.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Houston, US to Greenville, SC was searched and found on 28 Nov 2025 with a price of R 2 292To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Houston, US to Greenville, SC as early as possible.
You can expect to pay from R 2 292 to R 31 507 for a bus ticket from Houston, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 292, which is on 2025-11-28.
Usually Tornado Bus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Houston, US to Greenville, SC?
The bus is the cheapest travel choice for this destination
