Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Chicago (Union Station), IL | Greenville Station | Cheapest | ||||
| Train | Chicago (Union Station), IL | Greenville Station | Fastest |
Last refresh of the prices: Last Wednesday at 10:27 PM CST.
Compare 2 ways to go from Chicago to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 20 hours 50 minutes, and with fares starting at just $130, it presents an excellent value for a comfortable ride.
Train companies
Based on 5601 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $313
Frequently asked questions about travelling from Chicago to Greenville, SC by train
How much does a cheap train ticket from Chicago to Greenville cost?
The average train ticket price from Chicago to Greenville is $488. The best way to find cheap train tickets from Chicago to Greenville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the trip from Chicago to Greenville?
A train trip between Chicago and Greenville is around 1d 9h, although the fastest train will take about 1d 9h. This is the time it takes to travel the 904 km that separates the two cities.
How many daily trains are there between Chicago and Greenville?
The number of trains from Chicago to Greenville can differ depending on the day of the week. On average, there is 1. Some trains are direct while others have layovers. Simplify your train trip from Chicago to Greenville by comparing and selecting the train that fits your travel style and budget on Busbud.
Which train companies travel from Chicago to Greenville?
When taking the train from Chicago to Greenville, you can travel comfortably and safely with Amtrak.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Greenville, SC was searched and found on Nov 22, 2025 with a price of $574To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Chicago to Greenville, SC, as early as possible.
You can expect to pay from $574 to $2,005 for a train ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $1,550 which is on 2025-11-25.
