Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Chicago (Union Station), IL | Greenville Station | CheapestFastest | ||||
| Train | Chicago (Union Station), IL | Greenville Station | No tags |
Last refresh of the prices: Yesterday at 23:39 CST.
Compare 2 ways to travel from Chicago to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 20 hours 50 minutes and with fares starting at just £74, it presents an excellent value for a comfortable ride.
Train Companies
Based on 5614 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the Wi-Fi. Amtrak ticket prices on this trip start at £168
Frequently asked questions about travelling from Chicago to Greenville, SC by train
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much does a train ticket cost from Chicago to Greenville?
The cheapest train tickets from Chicago to Greenville start from £168. The average price for this train route is around £285. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the train journey from Chicago to Greenville?
The average train journey time from Chicago to Greenville is 1d 9h, covering a distance of 561 miles. The fastest train gets you there in 1d 9h and is operated by Amtrak.
Which train operators serve the Chicago to Greenville route?
Several major train operators run on this route with 1 trains available per day.
What are the earliest and latest departure times for the train from Chicago to Greenville?
The earliest train from Chicago to Greenville departs at 17:55. And the latest train departs at 18:40.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Greenville, SC was searched and found on 2 Dec 2025 with a price of £209To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Chicago to Greenville, SC as early as possible.
You can expect to pay from £209 to £954 for a train ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at £209, which is on 2025-12-02.
