How much is the bus ticket from Wilmington to Florence?

The cheapest bus tickets from Wilmington to Florence start from $92. The average price for this route is around $125. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Wilmington to Florence?

The average bus trip duration from Wilmington to Florence is 16h 15m, covering a distance of 447 miles (721 km). The quickest bus can get you there in 12h 55m and is operated by FlixBus .

Which bus companies service the Wilmington to Florence route?

Several major bus companies operate on this route with 6 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Wilmington to Florence?

The earliest bus departs from Wilmington to Florence at 11:20am. And the latest bus departs at 9:25pm.

What are the CO₂ emissions for the bus trip from Wilmington to Florence?

A bus trip from Wilmington to Florence generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Wilmington to Florence?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 11638 reviews.

Which bus company has the best Wi-Fi from Wilmington to Florence?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Wilmington to Florence?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Wilmington to Florence?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Wilmington to Florence from $105 | Refundable Tickets

Next bus departures

Next departures for Wilmington to Florence on December 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	7:30pm	Newark (DE)	16h 15m	11:45am	Bus station	Cheapest
	Bus	4:50pm	Newark (DE)	12h 55m	5:45am	Florence, SC	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	9:25pm	Wilmington Bus Station	14h 20m	11:45am	Bus station	No tags
	Bus	1:30pm	Delaware Rest Stop S	16h 15m	5:45am	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	1:50pm	Wilmington Bus Station	15h 55m	5:45am	Florence, SC	No tags

Next departures for Wilmington to Florence on December 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	7:30pm	Newark (DE)	16h 15m	11:45am	Bus station	Cheapest
	Bus	4:50pm	Newark (DE)	12h 55m	5:45am	Florence, SC	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	9:25pm	Wilmington Bus Station	14h 20m	11:45am	Bus station	No tags
	Bus	1:30pm	Delaware Rest Stop S	16h 15m	5:45am	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	1:50pm	Wilmington Bus Station	15h 55m	5:45am	Florence, SC	No tags

Next departures for Wilmington to Florence on December 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	9:25pm	Wilmington Bus Station	14h 20m	11:45am	Bus station	Cheapest
	Bus	4:50pm	Newark (DE)	12h 55m	5:45am	Florence, SC	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	1:50pm	Wilmington Bus Station	15h 55m	5:45am	Florence, SC	No tags
	Bus	1:30pm	Delaware Rest Stop S	16h 15m	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus	7:30pm	Newark (DE)	16h 15m	11:45am	Bus station	No tags

Last refresh of the prices: Yesterday at 7:24 AM EST.

Compare 2 ways to go from Wilmington to Florence

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Florence. The journey takes about 10 hours 1 minute and with fares starting at just $141, it presents an excellent value for a comfortable ride.

1train per day

10h 1mAverage Duration

447 milesDistance

66kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$92 - $268	Average Duration16h 15m	CO₂ emissions 18kg CO₂e
Train	Average Price$141 - $626	Average Duration10h 1m	CO₂ emissions 66kg CO₂e

Where are the popular stops in Wilmington and Florence?

Stops in Wilmington

A
Wilmington Bus Station
Wilmington Bus Station, 101 N French St, Wilmington, DE 19801, USA
Visit page
B
Wilmington Station
100 French St, Wilmington, DE 19801, USA
Visit page
C
Wilmington Bus Stop
101 N French , Wilmington, DE 19801

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

FlixBus

3.5/511,711 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,448 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Wilmington, DE to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Wilmington to Florence?
The cheapest bus tickets from Wilmington to Florence start from $92. The average price for this route is around $125. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Wilmington to Florence?
The average bus trip duration from Wilmington to Florence is 16h 15m, covering a distance of 447 miles (721 km). The quickest bus can get you there in 12h 55m and is operated by FlixBus.
Which bus companies service the Wilmington to Florence route?
Several major bus companies operate on this route with 6 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Wilmington to Florence?
The earliest bus departs from Wilmington to Florence at 11:20am. And the latest bus departs at 9:25pm.
What are the CO₂ emissions for the bus trip from Wilmington to Florence?
A bus trip from Wilmington to Florence generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Wilmington to Florence?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11638 reviews.
Which bus company has the best Wi-Fi from Wilmington to Florence?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Wilmington to Florence?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Wilmington to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/21

No data

12/22

$221

Today

$227

12/24

$105

12/25

$133

12/26

$197

12/27

$117

12/28

No data

The cheapest trip from Wilmington, DE to Florence, SC, US was searched and found on Dec 24, 2025 with a price of $105

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Florence, SC, US, as early as possible.

You can expect to pay from $105 to $227 for a bus ticket from Wilmington, DE to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $105 which is on 2025-12-24.