What is the distance between Baltimore and Florence?

The distance separating Baltimore and Florence is 389 miles (627 km).

What are the departure and arrival stations when taking the bus from Baltimore to Florence?

If you're headed to Florence from Baltimore, chances are that your bus will leave from Baltimore Downtown Bus Station and arrive at Florence Bus Station. These are the most popular pick-up and drop-off locations on this route, but you could find others that could be a better fit for your travel plans.

What are the best sights and things to do in Florence?

Once in Florence, you can start exploring the city and discover its surroundings. The top sights and things to do are Museo Galileo - Institute and Museum of the History of Science, Galleria degli Uffizi, Villa Gamberaia, Basilica Santa Croce and Galleria dell’Accademia.

Bus Baltimore to Florence from $50 | Refundable Tickets

Next bus departures

Next departures for Baltimore to Florence on November 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	8:30pm	Baltimore Downtown Bus Station	9h 15m	5:45am	Florence, SC	Cheapest
	Bus	11:10pm	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	8:00am	2301 W Lucas St.	Fastest
	Bus	11:45pm	Baltimore Downtown Bus Station	12h	11:45am	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:50pm	Baltimore Bus Stop	14h 55m	5:45am	Florence, SC	No tags

Next departures for Baltimore to Florence on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	8:30pm	Baltimore Downtown Bus Station	9h 15m	5:45am	Florence, SC	Cheapest
	Bus	11:10pm	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	8:00am	2301 W Lucas St.	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	1:35am	Baltimore Downtown Bus Station	10h 10m	11:45am	Bus station	No tags
	Bus	11:45pm	Baltimore Downtown Bus Station	12h	11:45am	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:50pm	Baltimore Bus Stop	14h 55m	5:45am	Florence, SC	No tags

Next departures for Baltimore to Florence on November 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	11:45pm	Baltimore Downtown Bus Station	12h	11:45am	Bus station	Cheapest
	Bus	11:10pm	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	8:00am	2301 W Lucas St.	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	1:35am	Baltimore Downtown Bus Station	10h 10m	11:45am	Bus station	No tags
	Bus	8:30pm	Baltimore Downtown Bus Station	9h 15m	5:45am	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:50pm	Baltimore Bus Stop	14h 55m	5:45am	Florence, SC	No tags

Next departures for Baltimore to Florence on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	11:10pm	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	8:00am	2301 W Lucas St.	CheapestFastest
FlixBus + Greyhound Lines, Inc.	Bus	1:35am	Baltimore Downtown Bus Station	10h 10m	11:45am	Bus station	No tags
	Bus	11:45pm	Baltimore Downtown Bus Station	12h	11:45am	Bus station	No tags
	Bus	8:30pm	Baltimore Downtown Bus Station	9h 15m	5:45am	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:50pm	Baltimore Bus Stop	14h 55m	5:45am	Florence, SC	No tags

Next departures for Baltimore to Florence on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	11:10pm	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	8:00am	2301 W Lucas St.	CheapestFastest
FlixBus + Greyhound Lines, Inc.	Bus	1:35am	Baltimore Downtown Bus Station	10h 10m	11:45am	Bus station	No tags
	Bus	11:45pm	Baltimore Downtown Bus Station	12h	11:45am	Bus station	No tags
	Bus	8:30pm	Baltimore Downtown Bus Station	9h 15m	5:45am	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:50pm	Baltimore Bus Stop	14h 55m	5:45am	Florence, SC	No tags

Last refresh of the prices: Yesterday at 8:12 PM EST.

Compare 2 ways to go from Baltimore to Florence

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 10 hours 10 minutes and with fares starting at just $58, it presents an excellent value for a comfortable ride.

4bus per day

10h 10mAverage Duration

391 milesDistance

16kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$58 - $196	Average Duration10h 10m	CO₂ emissions 16kg CO₂e
Train	Average Price$78 - $275	Average Duration9h 12m	CO₂ emissions 58kg CO₂e

Compare bus companies

Greyhound

3.5/587,384 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,380 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Wanda Coach

2.5/5647 reviews

Staff3

Timeliness2.8

Cleanliness2.5

Wifi1.7

Wanda Coach is one of the main Chinatown bus carriers in the US, connecting about 75 cities around the country with inexpensive tickets and comfortable bus rides. Wanda Coach buses travel between Chinatown neighborhoods with direct buses that are affordable, safe and have convenient pick-up and drop-off locations. If you travel with Wanda Coach, you can reschedule your tickets for a $10 fee up to 2 hours before travel time, and their buses have free WiFi, power outlets and bathrooms.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Baltimore and Florence?

Stops in Baltimore

A - Baltimore Downtown Bus Station

B - Penn Station

C - Baltimore Airport

D - Maryland Ave & I-83

Stops in Florence

A - Florence Bus Station

B - TA Travel Center - Florence

Frequently asked questions about traveling from Baltimore to Florence, SC, US by bus

What is the distance between Baltimore and Florence?
What are the departure and arrival stations when taking the bus from Baltimore to Florence?
What are the best sights and things to do in Florence?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/18

$98

11/19

$84

Today

$81

11/21

$77

11/22

$76

11/23

No data

11/24

$100

11/25

$100

The cheapest trip from Baltimore to Florence, SC, US was searched and found on Nov 22, 2025 with a price of $76

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Baltimore to Florence, SC, US, as early as possible.

You can expect to pay from $76 to $164 for a bus ticket from Baltimore to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $76 which is on 2025-11-22.

Usually Wanda Coach, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.