What is the distance between Baltimore and Florence?

The distance between Baltimore and Florence is around 627 km (389 miles).

What are the departure and arrival locations for buses traveling from Baltimore to Florence?

Buses traveling this route start their trip at Baltimore Downtown Bus Station, in Baltimore, and end it at Florence Bus Station, in Florence.

Bus Baltimore to Florence from $73 | Refundable Tickets

Next bus departures

Next departures for Baltimore to Florence on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	8:30pm	Baltimore Downtown Bus Station	9h 15m	5:45am	Florence, SC	CheapestFastest
FlixBus + Greyhound Lines, Inc.	Bus	1:35am	Baltimore Downtown Bus Station	10h 10m	11:45am	Bus station	No tags
	Bus	11:45pm	Baltimore Downtown Bus Station	12h	11:45am	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:50pm	Baltimore Bus Stop	14h 55m	5:45am	Florence, SC	No tags

Next departures for Baltimore to Florence on November 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	8:30pm	Baltimore Downtown Bus Station	9h 15m	5:45am	Florence, SC	Cheapest
	Bus	11:10pm	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	8:00am	2301 W Lucas St.	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	1:35am	Baltimore Downtown Bus Station	10h 10m	11:45am	Bus station	No tags
	Bus	11:45pm	Baltimore Downtown Bus Station	12h	11:45am	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:50pm	Baltimore Bus Stop	14h 55m	5:45am	Florence, SC	No tags

Last refresh of the prices: Last Saturday at 10:19 PM EST.

Compare 2 ways to go from Baltimore to Florence

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 10 hours 10 minutes, and with fares starting at just $83, it presents an excellent value for a comfortable ride.

5bus per day

10h 10mAverage Duration

630 kmDistance

16kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$83 - $300	Average Duration10h 10m	CO₂ emissions 16kg CO₂e
Train	Average Price$113 - $397	Average Duration9h 12m	CO₂ emissions 56kg CO₂e

Where are the popular stops in Baltimore and Florence?

Stops in Baltimore

A
Baltimore Downtown Bus Station
2110 Haines St, Baltimore, MD 21230, United States
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B
Penn Station
7 St Paul St, Baltimore, MD 21201, USA
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C
Baltimore Airport
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D
Maryland Ave & I-83
1578 Maryland Ave, Baltimore, MD 21201, USA
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Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

Greyhound

3.5/587,393 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

FlixBus

3.5/511,439 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Wanda Coach

2.5/5649 reviews

Staff3

Timeliness2.8

Cleanliness2.4

Wifi1.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Baltimore to Florence, SC, US by bus

What is the distance between Baltimore and Florence?
The distance between Baltimore and Florence is around 627 km (389 miles).
What are the departure and arrival locations for buses traveling from Baltimore to Florence?
Buses traveling this route start their trip at Baltimore Downtown Bus Station, in Baltimore, and end it at Florence Bus Station, in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-22

$110

11-23

$133

Today

$145

11-25

$261

11-26

$210

11-27

$126

11-28

$145

11-29

$138

The cheapest trip from Baltimore to Florence, SC, US was searched and found on Nov 22, 2025 with a price of $110

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Baltimore to Florence, SC, US, as early as possible.

You can expect to pay from $110 to $327 for a bus ticket from Baltimore to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $126 which is on 2025-11-27.

Usually Greyhound, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.