What's the distance between Baltimore and Florence by coach?

The distance between Baltimore and Florence by coach is approximately 389 miles (627 km).

What is the best way to go from Baltimore to Florence without flying?

You can choose the coach to travel this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You also have the option of utilising carpooling services.

Bus Baltimore to Florence from £39 | Refundable Tickets

Next bus departures

Next departures from Baltimore to Florence on 26 November
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	20:30	Baltimore Downtown Bus Station	9h 15m	05:45	Florence, SC	CheapestFastest
	Bus	23:45	Baltimore Downtown Bus Station	12h	11:45	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	14:50	Baltimore Bus Stop	14h 55m	05:45	Florence, SC	No tags

Next departures from Baltimore to Florence on 27 November
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	23:45	Baltimore Downtown Bus Station	12h	11:45	Bus station	Cheapest
	Bus	23:10	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	08:00	2301 W Lucas St.	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	01:35	Baltimore Downtown Bus Station	10h 10m	11:45	Bus station	No tags
	Bus	20:30	Baltimore Downtown Bus Station	9h 15m	05:45	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	14:50	Baltimore Bus Stop	14h 55m	05:45	Florence, SC	No tags

Next departures from Baltimore to Florence on 28 November
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	23:10	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	08:00	2301 W Lucas St.	CheapestFastest
FlixBus + Greyhound Lines, Inc.	Bus	01:35	Baltimore Downtown Bus Station	10h 10m	11:45	Bus station	No tags
	Bus	23:45	Baltimore Downtown Bus Station	12h	11:45	Bus station	No tags
	Bus	20:30	Baltimore Downtown Bus Station	9h 15m	05:45	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	14:50	Baltimore Bus Stop	14h 55m	05:45	Florence, SC	No tags

Next departures from Baltimore to Florence on 29 November
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	23:10	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	08:00	2301 W Lucas St.	CheapestFastest
FlixBus + Greyhound Lines, Inc.	Bus	01:35	Baltimore Downtown Bus Station	10h 10m	11:45	Bus station	No tags
	Bus	23:45	Baltimore Downtown Bus Station	12h	11:45	Bus station	No tags
	Bus	20:30	Baltimore Downtown Bus Station	9h 15m	05:45	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	14:50	Baltimore Bus Stop	14h 55m	05:45	Florence, SC	No tags

Next departures from Baltimore to Florence on 3 December
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	23:45	Baltimore Downtown Bus Station	12h	11:45	Bus station	Cheapest
	Bus	23:10	O'Donnell St. & Travel Plaza, Infront of TA Gas station	8h 50m	08:00	2301 W Lucas St.	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	01:35	Baltimore Downtown Bus Station	10h 10m	11:45	Bus station	No tags
	Bus	20:30	Baltimore Downtown Bus Station	9h 15m	05:45	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	14:50	Baltimore Bus Stop	14h 55m	05:45	Florence, SC	No tags

Last refresh of the prices: Yesterday at 20:56 EST.

Compare 2 ways to travel from Baltimore to Florence

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 10 hours 10 minutes and with fares starting at just £45, it presents an excellent value for a comfortable ride.

5bus per day

10h 10mAverage duration

391 milesDistance

16kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average price£45 - £162	Average duration10h 10m	CO₂ emissions 16kg CO₂e
Train	Average price£61 - £214	Average duration9h 12m	CO₂ emissions 58kg CO₂e

Where are the popular stops in Baltimore and Florence?

Stops in Baltimore

A
Baltimore Downtown Bus Station
2110 Haines St, Baltimore, MD 21230, United States
Visit page
B
Penn Station
7 St Paul St, Baltimore, MD 21201, USA
Visit page
C
Baltimore Airport
Visit page
D
Maryland Ave & I-83
1578 Maryland Ave, Baltimore, MD 21201, USA
Visit page

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

Greyhound

3.5/587,397 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

WiFi2.4

FlixBus

3.5/511,448 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

WiFi2.7

Wanda Coach

2.5/5649 reviews

Staff3

Timeliness2.8

Cleanliness2.4

WiFi1.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling by bus from Baltimore to Florence, SC, US

What's the distance between Baltimore and Florence by coach?
The distance between Baltimore and Florence by coach is approximately 389 miles (627 km).
What is the best way to go from Baltimore to Florence without flying?
You can choose the coach to travel this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

24/11

£78

25/11

£141

Today

£128

27/11

£70

28/11

£78

29/11

£78

30/11

£78

01/12

No data

The cheapest trip from Baltimore to Florence, SC, US was searched and found on 27 Nov 2025 with a price of £70

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Baltimore to Florence, SC, US as early as possible.

You can expect to pay from £70 to £176 for a bus ticket from Baltimore to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at £70, which is on 2025-11-27.

Usually Greyhound, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.