Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Newark (DE) | Bus station | Cheapest | ||||
 | Bus | Newark (DE) | Florence, SC | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Wilmington Bus Station | Bus station | No tags | ||||
| Bus | Delaware Rest Stop S | Florence, SC | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Wilmington Bus Station | Florence, SC | No tags |
Last refresh of the prices: Yesterday at 7:24 AM EST.
Compare 2 ways to go from Wilmington to Florence
Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 10 hours 1 minute, and with fares starting at just $198, it presents an excellent value for a comfortable ride.
Where are the popular stops in Wilmington and Florence?
Stops in Wilmington
- AWilmington Bus Station, 101 N French St, Wilmington, DE 19801, USA
- B100 French St, Wilmington, DE 19801, USA
- C
Wilmington Bus Stop
101 N French , Wilmington, DE 19801
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
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Frequently asked questions about travelling from Wilmington, DE to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Wilmington to Florence?
The cheapest bus tickets from Wilmington to Florence start from $129. The average price for this route is around $175. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Wilmington to Florence?
The average bus travel time from Wilmington to Florence is 16h 15m, covering a distance of 721 km. The quickest bus can get you there in 12h 55m and is operated by FlixBus.
Which bus companies service the Wilmington to Florence route?
What are the earliest and latest departure times for the bus from Wilmington to Florence?
The earliest bus departs from Wilmington to Florence at 11:20am. And the latest bus departs at 9:25pm.
What are the CO₂ emissions for the bus trip from Wilmington to Florence?
A bus trip from Wilmington to Florence generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Wilmington to Florence?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11648 reviews.
Which bus company has the best Wi-Fi from Wilmington to Florence?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Wilmington to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Wilmington to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Wilmington, DE to Florence, SC, US was searched and found on Dec 24, 2025 with a price of $147To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Florence, SC, US, as early as possible.
You can expect to pay from $147 to $318 for a bus ticket from Wilmington, DE to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $147 which is on 2025-12-24.
What's the cheapest way to go from Wilmington, DE to Florence, SC, US?
The bus is the cheapest travel choice for this destination
