Bus from Syracuse, US to Greenville, SC: Tickets & Schedules

Next bus departures

Next departures for Syracuse to Greenville on December 31
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
1116 Woodruff RdCheapestFastest

Last refresh of the prices: Yesterday at 10:10 AM EST.

Compare 2 ways to go from Syracuse to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 22 hours 15 minutes and with fares starting at just $115, it presents an excellent value for a comfortable ride.

2bus per day
22h 15mAverage Duration
657 milesDistance
26kgCO₂ emissions
Average Price$115 - $343Average Duration22h 15m
26kg CO₂e
Train
Average Price$201 - $231Average Duration22h 18m
97kg CO₂e

Frequently asked questions about traveling from Syracuse, US to Greenville, SC by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from Syracuse to Greenville?

    The cheapest bus tickets from Syracuse to Greenville start from $115. The average price for this route is around $178. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from Syracuse to Greenville?

    The average bus trip duration from Syracuse to Greenville is 22h 15m, covering a distance of 657 miles (1059 km). The quickest bus can get you there in 21h 50m and is operated by FlixBus.

  3. Which bus companies service the Syracuse to Greenville route?

    Several major bus companies operate on this route with 2 buses available per day, including services from FlixBus, Greyhound.

  4. What is the earliest and latest departure time for the bus from Syracuse to Greenville?

    The earliest bus departs from Syracuse to Greenville at 9:25am. And the latest bus departs at 9:00pm.

  5. What are the CO₂ emissions for the bus trip from Syracuse to Greenville?

    A bus trip from Syracuse to Greenville generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

  6. What is the best bus company from Syracuse to Greenville?

    According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11648 reviews.

  7. Which bus company has the best Wi-Fi from Syracuse to Greenville?

    Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

  8. Which bus company has the most timely service from Syracuse to Greenville?

    According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.

  9. Which bus company has the cleanest buses from Syracuse to Greenville?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12/29
No data
12/30
$267
Today
$230
busbud logoThe cheapest trip from Syracuse, US to Greenville, SC was searched and found on Dec 31, 2025 with a price of $230

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Greenville, SC, as early as possible.

What's the cheapest way to go from Syracuse, US to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

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