What is the distance between Syracuse and Greenville?

About 658 miles (1060 km) separate Syracuse and Greenville.

What are the departure and arrival stations when taking the bus from Syracuse to Greenville?

If you're headed to Greenville from Syracuse, chances are that your bus will leave from Regional Transportation Center and arrive at Guadalajara Supermarket Bus Stop. These are the primary departure and arrival locations on this route, but you can find others that could fit better into your travel plans.

Bus Syracuse to Greenville from $95 | Refundable Tickets

Next bus departures

Next departures for Syracuse to Greenville on November 18
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	9:00pm	Syracuse (Regional Transportation Center)	1d 11h	8:35am	1116 Woodruff Rd	Cheapest
	Bus	1:55pm	Syracuse (Regional Transportation Center)	23h 20m	1:15pm	1116 Woodruff Rd	Fastest
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 1h	10:50am	1116 Woodruff Rd	No tags

Last refresh of the prices: Yesterday at 10:44 AM EST.

Compare 2 ways to go from Syracuse to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 22 hours 20 minutes and with fares starting at just $106, it presents an excellent value for a comfortable ride.

3bus per day

22h 20mAverage Duration

657 milesDistance

26kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$106 - $268	Average Duration22h 20m	CO₂ emissions 26kg CO₂e
Train	Average Price$201 - $231	Average Duration22h 18m	CO₂ emissions 97kg CO₂e

Compare bus companies

FlixBus

3.5/511,326 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

FlixBus Syracuse Greenville recent customer reviews

It depended on the driver, as well as the cleanliness of each individual bus.

Marie S.

July 28, 2023

Greyhound

3.5/587,374 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Syracuse and Greenville?

Stops in Syracuse

A - Regional Transportation Center

B - Syracuse Airport

C - Syracuse University

D - Syracuse University - Lyman Hall

E - New York State Fairgrounds

F - Syracuse, NY

Stops in Greenville

A - Guadalajara Supermarket Bus Stop

B - Greenville Bus Station

Frequently asked questions about traveling from Syracuse, US to Greenville, SC by bus

What is the distance between Syracuse and Greenville?
What are the departure and arrival stations when taking the bus from Syracuse to Greenville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/13

$117

11/14

$122

Today

$117

11/16

$123

11/17

$116

11/18

$125

11/19

$114

11/20

$131

The cheapest trip from Syracuse, US to Greenville, SC was searched and found on Nov 19, 2025 with a price of $114

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Greenville, SC, as early as possible.

You can expect to pay from $114 to $164 for a bus ticket from Syracuse, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $114 which is on 2025-11-19.

Usually FlixBus, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.