Next departures for St. Louis to Charlotte on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Gateway Station
Charlotte Bus Station
Cheapest
Bus
Gateway Station
Charlotte (Freedom Dr)
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Gateway Station
Charlotte Bus Station
No tags
Bus
Gateway Station
Charlotte Bus Station
No tags
Bus
Gateway Station
Charlotte Bus Station
No tags
Last refresh of the prices: Yesterday at 1:33 PM CST.
Compare 2 ways to go from St. Louis to Charlotte
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Charlotte. The journey takes about 20 hours 25 minutes and with fares starting at just $106, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
4127 Glenwood Dr, Charlotte, NC 28208 (Exxon Gas Station)
Frequently asked questions about traveling from St. Louis to Charlotte, NC by bus
What is the travel distance from St. Louis to Charlotte?
The distance between the two cities is 567 miles (914 km).
What are the departure and arrival stations when taking the bus from St. Louis to Charlotte?
The majority of buses traveling from St. Louis to Charlotte start their journey at Gateway Station and wind up at Tornado & El Expreso Bus Company. These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$189
11/18
$110
Today
No data
11/20
$150
11/21
$110
11/22
$102
11/23
$115
11/24
No data
The cheapest trip from St. Louis to Charlotte, NC was searched and found on Nov 22, 2025 with a price of $102
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Charlotte, NC, as early as possible.
You can expect to pay from $102 to $229 for a bus ticket from St. Louis to Charlotte, NC based on the last 2 days. You can expect to find the cheapest price for the trip at $102 which is on 2025-11-22.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from St. Louis to Charlotte, NC?
The bus is the cheapest travel choice for this destination
The cheapest trip from St. Louis to Charlotte, NC was searched and found on Nov 22, 2025 with a price of $102
The bus is the cheapest travel choice for this destination
