Bus Tickets from Spartanburg to Chicago

Next bus departures

Next departures for Spartanburg to Chicago on November 19
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Spartanburg
Chicago 95Th & Dan RyanCheapestFastest
Greyhound Lines, Inc. + FlixBus
Bus
Spartanburg
Downtown Greyhound StationNo tags
Greyhound Lines, Inc.Bus
Spartanburg
Downtown Greyhound StationNo tags
FlixBus + Greyhound Lines, Inc.
Bus
Spartanburg
Downtown Greyhound StationNo tags
FlixBus + Greyhound Lines, Inc.
Bus
Spartanburg
537-517 W. Jackson BlvdNo tags

Last refresh of the prices: Yesterday at 6:38 PM EST.

Compare 2 ways to go from Spartanburg to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 20 hours 30 minutes and with fares starting at just $119, it presents an excellent value for a comfortable ride.

9bus per day
20h 30mAverage Duration
554 milesDistance
22kgCO₂ emissions
Average Price$119 - $291Average Duration20h 30m
22kg CO₂e
Average Price$208 - $1,577Average Duration1d 6h
83kg CO₂e

Frequently asked questions about traveling from Spartanburg to Chicago by bus

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/17
$157
11/18
No data
Today
$185
11/20
No data
11/21
No data
11/22
No data
11/23
No data
11/24
No data
busbud logoThe cheapest trip from Spartanburg to Chicago was searched and found on Nov 17, 2025 with a price of $157

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Spartanburg to Chicago, as early as possible.

What's the cheapest way to go from Spartanburg to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

People from around the world trust Busbud