Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Salisbury (Citgo Fast Stop) | Gateway Station | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Salisbury (Citgo Fast Stop) | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 8:25 PM EST.
Compare 2 ways to go from Salisbury to St. Louis
Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 23 hours 5 minutes and with fares starting at just $124, it presents an excellent value for a comfortable ride.
Where are the popular stops in Salisbury and St. Louis?
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Salisbury, NC, US to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Salisbury to St. Louis?
The cheapest bus tickets from Salisbury to St. Louis start from $124. The average price for this route is around $161. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Salisbury to St. Louis?
The average bus trip duration from Salisbury to St. Louis is 23h 5m, covering a distance of 574 miles (926 km). The quickest bus can get you there in 21h 50m and is operated by Greyhound.
Which bus companies service the Salisbury to St. Louis route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Salisbury to St. Louis?
The earliest bus departs from Salisbury to St. Louis at 6:15am. And the latest bus departs at 7:05pm.
What are the CO₂ emissions for the bus trip from Salisbury to St. Louis?
A bus trip from Salisbury to St. Louis generates an estimated 23 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Salisbury, NC, US to St. Louis was searched and found on Dec 3, 2025 with a price of $128To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Salisbury, NC, US to St. Louis, as early as possible.
You can expect to pay from $128 to $270 for a bus ticket from Salisbury, NC, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $128 which is on 2025-12-03.
What's the cheapest way to go from Salisbury, NC, US to St. Louis?
The bus is the cheapest travel choice for this destination
