Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Prague (Central Bus Station Florenc) | Perrache | No tags | ||||
| Bus | Prague (Na Knížecí) | Aéroport LYS | No tags | ||||
| Bus | Prague (Na Knížecí) | Perrache | No tags | ||||
| Bus | PRG Airport | Perrache | No tags | ||||
| Bus | Prague (Main Station - parking) | Perrache | No tags |
Get from Prague to Lyon
The journey takes about 18 hours 30 minutes and with fares starting at just $61, it presents an excellent value for a comfortable ride.
Where are the popular stops in Prague and Lyon?
Stops in Prague
- AAviatická, 161 08, Praha 6, Czechia
- B
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - CKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- DChlumecká, 198 00 Praha 20, Czech Republic
- ETomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- F300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Lyon
- ARue de Esplanade, 69002 Lyon, France
- C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - FLes Charrières, 69570 Dardilly, France
Compare bus companies
Frequently asked questions about traveling from Prague to Lyon by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Prague to Lyon?
The cheapest bus tickets from Prague to Lyon start from $61. The average price for this route is around $90. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Lyon?
The average bus trip duration from Prague to Lyon is 18h 30m, covering a distance of 529 miles (854 km). The quickest bus can get you there in 14h 35m and is operated by FlixBus.
Which bus companies service the Prague to Lyon route?
Several major bus companies operate on this route with 8 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What is the earliest and latest departure time for the bus from Prague to Lyon?
The earliest bus departs from Prague to Lyon at 3:50am. And the latest bus departs at 11:00pm.
What are the CO₂ emissions for the bus trip from Prague to Lyon?
A bus trip from Prague to Lyon generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Prague to Lyon?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1058 reviews.
Which bus company has the best Wi-Fi from Prague to Lyon?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Prague to Lyon?
According to Busbud traveller reviews, the most timely bus company on this route is RegioJet, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Prague to Lyon?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Lyon was searched and found on Dec 18, 2025 with a price of $64To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Lyon, as early as possible.
You can expect to pay from $64 to $164 for a bus ticket from Prague to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $72 which is on 2025-12-22.
