Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Prague (Central Bus Station Florenc) | Perrache | Cheapest | ||||
| Bus | Prague (Na Knížecí) | Perrache | Fastest | ||||
| Bus | Prague (Central Bus Station Florenc) | Perrache | No tags | ||||
| Bus | Prague (Central Bus Station Florenc) | Perrache | No tags | ||||
| Bus | Prague (Main Station - parking) | Perrache | No tags |
Last refresh of the prices: Today at 9:23 AM CET.
Get from Prague to Lyon
The journey takes about 18 hours 30 minutes, and with fares starting at just R 1 048, it presents an excellent value for a comfortable ride.
Where are the popular stops in Prague and Lyon?
Stops in Prague
- AAviatická, 161 08, Praha 6, Czechia
- B
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - CKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- DChlumecká, 198 00 Praha 20, Czech Republic
- ETomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- F300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Lyon
- ARue de Esplanade, 69002 Lyon, France
- B
Lyon Airport
- C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - FLes Charrières, 69570 Dardilly, France
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Frequently asked questions about travelling from Prague to Lyon by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Prague to Lyon?
The cheapest bus tickets from Prague to Lyon start at R 1 048. The average price for this route is around R 1 541. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Prague to Lyon?
The average bus journey time from Prague to Lyon is 18h 30m, covering a distance of 854 km. The fastest bus gets you there in 14h 35m and is operated by FlixBus.
Which bus companies service the Prague to Lyon route?
Several major bus companies operate on this route with 8 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What is the earliest and latest departure time for the bus from Prague to Lyon?
The earliest bus departs from Prague to Lyon at 03:50. And the latest bus departs at 23:00.
What are the CO₂ emissions for the bus trip from Prague to Lyon?
A bus trip from Prague to Lyon produces an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Prague to Lyon?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1058 reviews.
Which bus company has the best Wi-Fi from Prague to Lyon?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company offers the most punctual service from Prague to Lyon?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Prague to Lyon?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Lyon was searched and found on 18 Dec 2025 with a price of R 1 098To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Lyon as early as possible.
You can expect to pay from R 1 098 to R 3 363 for a bus ticket from Prague to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 223, which is on 2025-12-22.
