Next departures for Prague to Frankfurt am Main on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Prague (Central Bus Station Florenc)
Frankfurt Hbf
Cheapest
Florenc
Frankfurt - Main bus station
Fastest
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Flixbus + Flixtrain
PRG Airport
Südbahnhof
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Next departures for Prague to Frankfurt am Main on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Florenc
Frankfurt - Main bus station
CheapestFastest
Florenc
Frankfurt central
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Flixbus + Flixtrain
PRG Airport
Südbahnhof
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Next departures for Prague to Frankfurt am Main on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Florenc
Frankfurt - Main bus station
CheapestFastest
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Flixbus + Flixtrain
PRG Airport
Südbahnhof
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Flixbus + Flixtrain
Prague (Central Bus Station Florenc)
Südbahnhof
No tags
Next departures for Prague to Frankfurt am Main on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Florenc
Frankfurt - Main bus station
CheapestFastest
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Next departures for Prague to Frankfurt am Main on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Florenc
Frankfurt - Main bus station
CheapestFastest
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Next departures for Prague to Frankfurt am Main on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
Cheapest
Florenc
Frankfurt - Main bus station
Fastest
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Next departures for Prague to Frankfurt am Main on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Prague (Central Bus Station Florenc)
Frankfurt Hbf
Cheapest
Florenc
Frankfurt - Main bus station
Fastest
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Flixbus + Flixtrain
PRG Airport
Südbahnhof
No tags
Prague (Central Bus Station Florenc)
FRA Frankfurt airport
No tags
Last refresh of the prices: Yesterday at 11:07 PM CET.
Compare 3 ways to go from Prague to Frankfurt am Main
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Frankfurt am Main. The journey takes about 5 hours 10 minutes and with fares starting at just $24, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 1057 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the departure location and the value for money but often complained with the wifi. RegioJet ticket prices on this trip start at $34
Based on 19 reviews, the company was rated 4.2 stars on Busbud. Travelers were especially satisfied with the staff and the seats but often complained with the timeliness. KLR Bus ticket prices on this trip start at $23
Based on 11143 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $30
LEX CLUB offers 1 daily departures, and you can find tickets starting at $32. The quickest ride takes around 710. LEX CLUB offers a cost-effective solution to get you where you need to be.
Frequently asked questions about traveling from Prague to Frankfurt am Main by bus
How far is Prague from Frankfurt am Main?
Prague and Frankfurt am Main are 254 miles (410 km) apart.
What are the departure and arrival stations when taking the bus from Prague to Frankfurt am Main?
Most of the buses traveling from Prague to Frankfurt am Main leave from Černý Most and arrive at Frankfurt Airport. These are the most popular pick-up and drop-off locations on this route, but you can also find other options that could better fit your plans.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
$31
11/20
$42
Today
$36
11/22
$31
11/23
$36
11/24
$31
11/25
$31
11/26
$28
The cheapest trip from Prague to Frankfurt am Main was searched and found on Nov 26, 2025 with a price of $28
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Frankfurt am Main, as early as possible.
You can expect to pay from $28 to $112 for a bus ticket from Prague to Frankfurt am Main based on the last 2 days. You can expect to find the cheapest price for the trip at $28 which is on 2025-11-26.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Prague to Frankfurt am Main was searched and found on Nov 26, 2025 with a price of $28
