How much is the bus ticket from Pittsburgh to Greenville?

The cheapest bus tickets from Pittsburgh to Greenville start from $90. The average price for this route is around $139. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Pittsburgh to Greenville?

The average bus trip duration from Pittsburgh to Greenville is 20h 50m, covering a distance of 408 miles (657 km). The quickest bus can get you there in 17h 35m and is operated by Greyhound .

Which bus companies service the Pittsburgh to Greenville route?

Several major train operators operate on this route with 4 trains available per day.

What is the earliest and latest departure time for the bus from Pittsburgh to Greenville?

The earliest bus departs from Pittsburgh to Greenville at 1:30am. And the latest bus departs at 9:00pm.

What are the CO₂ emissions for the bus trip from Pittsburgh to Greenville?

A bus trip from Pittsburgh to Greenville generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

Bus Pittsburgh to Greenville from $81 | Refundable Tickets

Next bus departures

Next departures for Pittsburgh to Greenville on January 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	9:35am	Pittsburgh Intermodal Station	1d 3h	1:15pm	1116 Woodruff Rd	Cheapest
	Bus	9:00pm	Pittsburgh Intermodal Station	17h 35m	2:35pm	1116 Woodruff Rd	Fastest
	Bus	1:35am	Pittsburgh Intermodal Station	1d 5h	7:05am	1116 Woodruff Rd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:30am	Pittsburgh Intermodal Station	1d	8:35am	1116 Woodruff Rd	No tags

Next departures for Pittsburgh to Greenville on January 16
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	9:00pm	Pittsburgh Intermodal Station	17h 35m	2:35pm	1116 Woodruff Rd	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	1:30am	Pittsburgh Intermodal Station	17h 55m	7:25pm	1116 Woodruff Rd	No tags
	Bus	1:35am	Pittsburgh Intermodal Station	1d 5h	7:05am	1116 Woodruff Rd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	11:45am	Pittsburgh Intermodal Station	20h 50m	8:35am	1116 Woodruff Rd	No tags

Next departures for Pittsburgh to Greenville on January 17
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:45am	Pittsburgh Intermodal Station	20h 50m	8:35am	1116 Woodruff Rd	Cheapest
	Bus	9:00pm	Pittsburgh Intermodal Station	17h 35m	2:35pm	1116 Woodruff Rd	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	1:30am	Pittsburgh Intermodal Station	17h 55m	7:25pm	1116 Woodruff Rd	No tags
	Bus	1:35am	Pittsburgh Intermodal Station	1d 5h	7:05am	1116 Woodruff Rd	No tags

Next departures for Pittsburgh to Greenville on January 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:45am	Pittsburgh Intermodal Station	23h 5m	10:50am	1116 Woodruff Rd	Cheapest
	Bus	9:00pm	Pittsburgh Intermodal Station	17h 35m	2:35pm	1116 Woodruff Rd	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	1:30am	Pittsburgh Intermodal Station	17h 55m	7:25pm	1116 Woodruff Rd	No tags
	Bus	1:35am	Pittsburgh Intermodal Station	1d 5h	7:05am	1116 Woodruff Rd	No tags

Last refresh of the prices: Today at 1:36 PM EST.

Compare 2 ways to go from Pittsburgh to Greenville

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as the good way to reach Greenville. The journey takes about 20 hours 50 minutes and with fares starting at just $90, it presents an excellent value for a comfortable ride.

4bus per day

20h 50mAverage Duration

408 milesDistance

16kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$90 - $359	Average Duration20h 50m	CO₂ emissions 16kg CO₂e
Train	Average Price$146 - $1,457	Average Duration23h 59m	CO₂ emissions 60kg CO₂e

Where are the popular stops in Pittsburgh and Greenville?

Stops in Pittsburgh

A
Intermodal Station
55 11th St, Pittsburgh, PA 15222, USA
Visit page Map
B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
Map

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
Map
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Map

Compare bus companies

Greyhound

3.5/587,500 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Pittsburgh to Greenville, SC by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Pittsburgh to Greenville?
The cheapest bus tickets from Pittsburgh to Greenville start from $90. The average price for this route is around $139. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pittsburgh to Greenville?
The average bus trip duration from Pittsburgh to Greenville is 20h 50m, covering a distance of 408 miles (657 km). The quickest bus can get you there in 17h 35m and is operated by Greyhound.
Which bus companies service the Pittsburgh to Greenville route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Pittsburgh to Greenville?
The earliest bus departs from Pittsburgh to Greenville at 1:30am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Pittsburgh to Greenville?
A bus trip from Pittsburgh to Greenville generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/12

$148

01/13

$151

Today

$152

01/15

$184

01/16

$128

01/17

$139

01/18

$129

01/19

$128

The cheapest trip from Pittsburgh to Greenville, SC was searched and found on Jan 16, 2026 with a price of $128

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Greenville, SC, as early as possible.

You can expect to pay from $128 to $192 for a bus ticket from Pittsburgh to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $128 which is on 2026-01-16.