Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Milan (Assago M2) | Terminal Interbus | No tags | ||||
| Bus | Milan (Malpensa Aeroporto Terminal 1) | Terminal Interbus | No tags | ||||
| Bus | Aeroporto Malpensa T2 | Terminal Interbus | No tags | ||||
| Bus | Lampugnano bus station | Terminal Interbus | No tags | ||||
| Bus | Milan (San Donato M3) | Terminal Interbus | No tags |
Compare 3 ways to go from Milano to Syracuse
Among the sustainable travel choices, the bus stands out as the good way to reach Syracuse. The journey takes about 1 day, 3 hours 10 minutes and with fares starting at just $58, it presents an excellent value for a comfortable ride.
Where are the popular stops in Milano and Syracuse?
Stops in Milano
- APiazza I Maggio, 1, 20099 Sesto San Giovanni MI, Italy
- BVia Giulio Natta, 228, 20151 Milano, Italy
- EVia Giuseppe Impastato, 27, 20138 Milano, Italy
- F
Molino Dorino
Molino Dorino, 20151 Milano, Italy
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Milano to Syracuse by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Milano to Syracuse?
The cheapest bus tickets from Milano to Syracuse start from $58. The average price for this route is around $96. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Milano to Syracuse?
The average bus trip duration from Milano to Syracuse is 1d 3h, covering a distance of 657 miles (1059 km). The quickest bus can get you there in 20h 40m and is operated by FlixBus.
Which bus companies service the Milano to Syracuse route?
Several major train operators operate on this route with 6 trains available per day.
What is the earliest and latest departure time for the bus from Milano to Syracuse?
The earliest bus departs from Milano to Syracuse at 12:55pm. And the latest bus departs at 9:30pm.
What are the CO₂ emissions for the bus trip from Milano to Syracuse?
A bus trip from Milano to Syracuse generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milano to Syracuse was searched and found on Dec 3, 2025 with a price of $54To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milano to Syracuse, as early as possible.
You can expect to pay from $54 to $145 for a bus ticket from Milano to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at $54 which is on 2025-12-03.
What's the cheapest way to go from Milano to Syracuse?
The bus is the cheapest travel choice for this destination
