Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Milan (Assago M2) | Terminal Interbus | No tags | ||||
| Bus | Milan (Malpensa Aeroporto Terminal 1) | Terminal Interbus | No tags | ||||
| Bus | Aeroporto Malpensa T2 | Terminal Interbus | No tags | ||||
| Bus | Lampugnano bus station | Terminal Interbus | No tags | ||||
| Bus | Milan (San Donato M3) | Terminal Interbus | No tags |
Compare 3 ways to go from Milano to Syracuse
Among the sustainable travel choices, the bus stands out as a good way to reach Syracuse. The journey takes about 1 day, 3 hours 10 minutes, and with fares starting at just $83, it presents an excellent value for a comfortable ride.
Where are the popular stops in Milano and Syracuse?
Stops in Milano
- APiazza I Maggio, 1, 20099 Sesto San Giovanni MI, Italy
- BVia Giulio Natta, 228, 20151 Milano, Italy
- EVia Giuseppe Impastato, 27, 20138 Milano, Italy
- F
Molino Dorino
Molino Dorino, 20151 Milano, Italy
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Compare bus companies
Based on 11444 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $83
Frequently asked questions about travelling from Milano to Syracuse by bus
What is the travel distance from Milano to Syracuse?
Milano and Syracuse are 1064 km (660 miles) apart.
What are the departure and arrival locations for buses traveling from Milano to Syracuse?
Buses departing from Piazza I Maggio, 1 in Milano will take you to Fermata dell'autobus Siracusa in Syracuse.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milano to Syracuse was searched and found on Nov 24, 2025 with a price of $78To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milano to Syracuse, as early as possible.
You can expect to pay from $78 to $150 for a bus ticket from Milano to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at $87 which is on 2025-12-01.
What's the cheapest way to go from Milano to Syracuse?
The bus is the cheapest travel choice for this destination
